偏头痛患者外周血淋巴细胞5-羟色胺1D受体基因表达的研究  

Study on the 5 HT 1D receptor gene expression of peripheral lymphocytes in the patients with migraine

作　　者：王宝祥[1,2] 陈宝田[1,2] 刘毅 谢炜[1,2] 罗仁 战胜才[1,2] 

机构地区：[1]空军济南医院 [2]第一军医大学中医系内科

出　　处：《中华神经科杂志》1997年第5期294-296,共3页Chinese Journal of Neurology

基　　金：全军医药卫生八五攻关课题

摘　　要：目的探讨５－羟色胺１Ｄ（５－ＨＴ１Ｄ）受体基因表达与５－ＨＴ在偏头痛发作中的作用。方法采用反转录－聚合酶链反应技术，检测３２例偏头痛患者外周血淋巴细胞５－ＨＴ１Ｄ受体基因表达、血浆５－ＨＴ含量的变化。结果偏头痛患者发作期５－ＨＴ１Ｄ受体基因表达阳性率为９３．８％，对照组表达为５．０％，两者比较差异有显著意义；间歇期受体表达为５３．３％，与发作期比较差异有显著意义；发作期血浆５－ＨＴ含量明显低于对照组和间歇期。结论５－ＨＴ含量异常可能是偏头痛的发病基础，５－ＨＴ１Ｄ受体可能是偏头痛发作的参与者，５－ＨＴ１Ｄ受体基因表达对偏头痛的诊断有重要意义。Objective To explore the mechanism of 5 HT 1D receptor gene expressions and 5 HT in migraine. Methods The 5 HT 1D receptor gene expressions of the peripheral lymphocytes was tested with reverse transcription polymerase chain reaction (RT PCR) and the concentration of plasma 5 HT was also tested. Results It was showed that the 5 HT 1D receptor expressions in the normal control group were 5.0%, while those in the patients with migraine episodes was 93.8%, which was markedly higher than those in the normal control group. There was a great significance between the differences. The 5 HT 1D receptor expressions in the patients in the interim stage was 53.3%. There were remarkable significances as compared with those in the patients in the episode stage. The concentrations of plasma 5 HT levels were markedly lower in patients with migraine than those in the normal control group and those in the interim stage. Conclusion These results revealed that the changes of the concentrations of plasma 5 HT might act as a basis for dereloping the migraine and the 5 HT 1D receptors could take part in the process of the episodes of migraine. The 5 HT 1D receptor gene expressions might have an important significance for the diagnosis of migraine.

关 键 词：偏头痛 受体 基因表达 5-羟色胺 淋巴细胞 

分 类 号：R747.2[医药卫生—神经病学与精神病学]