急性早幼粒细胞白血病与MHC-A^＊基因的相关研究  

MHC—A*gene polymorphism in patients with acute promyelocyti leukemia

作　　者：李金梅[1] 曹峰林[1] 汤海蒂[1] 刘秀华[1] 周晋[1] 

机构地区：[1]哈尔滨医科大学第一临床医学院血液科哈尔滨医科大学干细胞与生殖医学研究所,卫生部细胞移植重点实验室,哈尔滨150001

出　　处：《中国优生与遗传杂志》2008年第3期59-60,共2页Chinese Journal of Birth Health & Heredity

摘　　要：目的探讨北方地区汉族人急性早幼粒细胞白血病(APL)与人类主要组织相容性复合体MHC—A*基因多态性的关系。方法应用顺序特异性引物和聚合酶链反应(PCR-SSP)技术,对21例急性早幼粒细胞白血病患者及29例无血缘关系的健康人的MHC—A*各等位基因及亚基因进行了检测分析。结果结果表明,MHC—A*11(RR=5·333,P<0·05=;和MHC—A*24(RR=3·60,P<0·05=基因与APL呈正相关,显著高于对照组,两组之间比较差异有显著性意义,而其它MHC—A*各等位基因未见异常,均无统计学差异。结论本项研究结果提示,MHC—A*11和24基因可能是我国北方汉族人APL致病的易感基因,为揭示APL的发病机制中免疫遗传学作用提供了重要信息和依据。Objective： In order to study the correlativity between MHC-A ＊ gene polymorphism and acute promyelocyti leukemia （APE）. Methods： MHC-A ＊ gene polymorphism in 21 patients with APL and 29 normal control subjects was analyzed by using the polymerease chain reaction ／ sequence specific primer （ PCR ／ SSP） technique. Results ： MHC-A ＊ 11 （ RR =5,333, P 〈 0. 05 = ; MHC-A ＊ 24 （ RR = 3.60, P 〈 0. 05 =. The frequency of MHC - A ＊ 11 and 24 allele was significantly higher in patients than that in the controls. Conclusion： These findings further verify that immunogenetics play a predominant Pathogenetics role in a subset of APL patients. Individuals carrying MHC - A ＊ 11 and 24 alleles may be susceptibility gene to APL. This method is more specific, sensitive, simple, rapid and accurate, and could be applied to the routine clinical detective.

关 键 词：急性早幼粒细胞白血病(APL) 人类主要组织相容性复合体(MHC) 基因多态性 

分 类 号：R733.7[医药卫生—肿瘤]