颌下腺肿瘤动物模型的建立  

The construction of animal model of submandibular gland tumor

作　　者：马长路[1,2] 刘学军[1,2] 曹选平[1,2] 张云汉[1,2] 郝志芳[1,2] 张红新 赵庆夏[1,2] 

机构地区：[1]河南医科大学第一附属医院病理科 [2]河南医科大学口腔系

出　　处：《河南医科大学学报》1997年第3期60-62,共3页Journal of Henan Medical University

摘　　要：为了研究涎腺肿瘤的发生和发展规律，建立涎腺肿瘤动物模型。采用化学致癌物———三甲基胆蒽对４６只ＳＤ大鼠颌下腺腺体内进行直接注射的方法，观察诱发产生颌下腺肿瘤情况。结果：共诱发产生肿瘤３４例，其中鳞状细胞癌４例，平滑肌肉瘤３０例。提示：三甲基胆蒽可诱发大鼠颌下腺产生肿瘤，并以肉瘤多见。In order to study the genesis and the developing regulation of salivary gland tumor and establish salivary gland tumor model,the induced tumor of submandibular gland was observed by using the direct injection of chemical carcinogen——3 Methylcholanthrene in 46 SD rats.The results showed that 34 tumors were induced,4 squamous cell carcinoma,30 leiomyosarcoma in total.The results indicate that the submandibular gland tumor can be induced by 3 methylcholanthrene,and sarcoma was of high incidence.

关 键 词：三甲基胆蒽 颌下腺肿瘤 动物模型 大鼠 

分 类 号：R73－35[医药卫生—肿瘤]