支气管相关淋巴组织研究进展  

Advances in research of bronchus-associated lymphoid tissue

作　　者：陈华夏[1] 高金明[1] 郭子建[1] 

机构地区：[1]北京协和医院呼吸内科,100730

出　　处：《国际呼吸杂志》2008年第6期364-367,共4页International Journal of Respiration

基　　金：国家自然科学基金项目（30470768、30470767）

摘　　要：支气管相关淋巴组织（bronchus—associated lymphoid tissue，BALT）是支气管内能够对吸入的抗原发生B细胞和T细胞免疫应答的淋巴细胞集合体。大部分BALT位于人或动物支气管分叉处，具有相对特异的组织特征。BALT从胎儿期即开始出现，抗原刺激可以加速BALT的发育。BALT引发的体液免疫应答主要是局部B细胞的应答和免疫球蛋白IgA的应答，是黏膜免疫系统的组成部分。Bronchus-associated lymphoid tissue（BALT） constitutes organized lymphoid aggregates that are capable of T-and B-cell responses to inhaled antigens. BALT, located mostly at bifurcations of the bronchus in animals and humans, is present in the fetus and develops rapidly in the presence of antigens. Humoral immune responses elicited by BALT are primarily B cell and immumoglobulin A responses. BALT is considered as a member of the common mucosal immunologic system.

关 键 词：支气管相关淋巴组织 免疫应答 淋巴瘤 

分 类 号：R734.1[医药卫生—肿瘤]