阿尔茨海默病海马体积的MR研究  

The MR Study about Volume of Hippocampus of Alzheimer Disease

作　　者：王峥超[1] 王冬青[1] 许云飞[1] 朱颖[1] 于寅尧[1] 刘文[1] 李月峰[1] 

机构地区：[1]江苏大学附属医院,江苏镇江212001

出　　处：《河北医学》2008年第2期148-151,共4页Hebei Medicine

摘　　要：目的:探讨阿尔茨海默病患者海马结构体积的变化。方法:应用3.0T磁共振分别对35例阿尔茨海默病患者和25例健康志愿者的海马体积进行测量并行统计学分析,对比二者体积之间的差异。结果:健康志愿者组左侧海马体积为3.006±0.335cm3,右侧为3.001±0.341 cm3,阿尔茨海默病患者组左侧海马体积为2.153±0.380 cm3,右侧为2.146±0.361 cm3,阿尔茨海默病患者组海马体积与健康志愿者组存在显著的统计学差异(P<0.01)。结论:阿尔茨海默病与海马结构体积异常具有一定的相关性,对阿尔茨海默病患者海马结构体积进行研究能够为临床诊断提供参考价值。Objective ：To study variation of the volume of hippocampus in AD patients. Method： Thirty - five AD patients and twenty - five normal control subjects were performed on 3.0 T MRI in the study. We statisticsed the data of volume of their hippocampus, and contrasted the differences between the two. Result： The volume of left hippocampus in normal control subjects was 3. 006 ± 0. 335cm^3, the right was 3. 001 ±0. 341 cm^3 ,the volume of left hippocampus in the patients of AD was 2. 153 ±0. 380 cm^3 ,the right was 2. 146 ±0. 361 cm^3. There were significant differences between the patients of AD and the control subjects（ P 〈0. 01 ）. Conclusion： AD was found to have certain associativity with the abnormality of volume of hippocampus, and the study of it has value for clinical diagnosis of AD.

关 键 词：阿尔茨海默病 磁共振成像 海马 

分 类 号：R749.16[医药卫生—神经病学与精神病学]