Complications of collagenous colitis  

作　　者：Hugh James Freeman 

机构地区：[1]Department of Medicine(Gastroen-terology),University of British Columbia,Vancouver V6T 1W5,Canada

出　　处：《World Journal of Gastroenterology》2008年第11期1643-1645,共3页世界胃肠病学杂志（英文版）

摘　　要：Microscopic forms of colitis have been described, including collagenous colitis. This disorder generally has an apparently benign clinical course. However, a number of gastric and intestinal complications, possibly coincidental, may develop with collagenous colitis. Distinctive inflammatory disorders of the gastric mucosa have been described, including lymphocytic gastritis and collagenous gastritis. Celiac disease and collagenous sprue （or collagenous enteritis） may occur. Colonic ulceration has been associated with use of nonsteroidal anti-inflammatory drugs, while other forms of inflammatory bowel disease, including ulcerative colitis and Crohn＇s disease, may evolve from coUagenous colitis. Submucosal ＂dissection＂, colonic fractures or mucosal tears and perforation from air insufflation during colonoscopy may occur and has been hypothesized to be due to compromise of the colonic wall from submucosal collagen deposition. Similar changes may result from increased intraluminal pressure during barium enema contrast studies. Finally, malignant disorders have also been reported, including carcinoma and lymphoproliferative disease.Microscopic forms of colitis have been described, including collagenous colitis.This disorder generally has an apparently benign clinical course.However, a number of gastric and intestinal complications, possibly coincidental,may develop with collagenous colitis.Distinctive inflammatory disorders of the gastric mucosa have been described,including lymphocytic gastritis and collagenous gastritis.Celiac disease and collagenous sprue(or collagenous enteritis)may occur. Colonic ulceration has been associated with use of nonsteroidal anti-inflammatory drugs,while other forms of inflammatory bowel disease,including ulcerative colitis and Crohn's disease,may evolve from collagenous colitis.Submucosal"dissection",colonic fractures or mucosal tears and perforation from air insufflation during colonoscopy may occur and has been hypothesized to be due to compromise of the colonic wall from submucosal collagen deposition.Similar changes may result from increased intraluminal pressure during barium enema contrast studies.Finally,malignant disorders have also been reported,including carcinoma and lymphoproliferative disease.

关 键 词：Colonic fractures Colonic perforation Celiac disease Collagenous gastritis Collagenous sprue Cat scratch colon Colon cancer Microscopic colitis 

分 类 号：R574.6[医药卫生—消化系统]