胃癌患者血清血管内皮钙黏蛋白水平及其临床意义  

Serum level of vascular endothelial-cadherin in patients with gastric cancer and its clinical significance

作　　者：刘斌[1] 唐建荣[1] 黄世锋[1] 

机构地区：[1]广西医科大学第四附属医院,广西柳州市工人医院普外一病区,545005

出　　处：《实用医学杂志》2008年第5期752-754,共3页The Journal of Practical Medicine

摘　　要：目的:检测胃癌患者血清中血管内皮钙黏蛋白(VE-cadherin)的含量并探讨其临床意义。方法:采用酶联免疫吸附分析法(ELISA)对60例经病理证实的术前胃癌患者、40例慢性胃炎患者和40例正常健康者血清VE-cadherin水平进行检测。结果:胃癌患者血清VE-cadherin水平明显高于慢性胃炎患者和正常健康者(P<0.01)。胃癌患者血清VE-cadherin水平与肿瘤大小有关(P<0.05),与性别、年龄、浸润深度、淋巴结转移、远处转移、分化程度不相关(P>0.05)。结论:VE-cadherin可能与胃癌的发生有关,与肿瘤大小正相关。Objective To detect serum level of vascular endothelial-cadherin （VE-cadherin） in patients with gastric cancer and to explore its clinical significance. Methods Serum levels of VE-cadherin were measured using ELISA in 60 presurgical patients with gastric cancer confirmed by pathology, 40 with chronic gastritis, and 40 healthy individuals. Results The serum VE-cadherin levels in gastric cancer were significantly higher than those in chronic gastritis or in the healthy individuals （P 〈 0.01 for both comparisons）. Serum VE-cadherin level was correlated with tumor size （P 〈 0.05） but unrelated to sex, age, depth of infiltration, lymph node metastases, distant metastases, and degree of the cell differentiation （P 〉 0.05 for all comparisons）. Conclusion Serum VE-cadherin level may be involved in the genesis of gastric cancer and is positively correlated with tumor size.

关 键 词：胃肿瘤 血管内皮钙黏蛋白 血清 酶联免疫吸附分析法 

分 类 号：R735.2[医药卫生—肿瘤]