含不同药物排龈线引起牙龈炎症的比较研究  

Evaluation of gingival inflammation related to different retraction agents

作　　者：孙学武 孙桂兰[2] 肖丽静 

机构地区：[1]烟台市口腔医院修复科,山东烟台264000 [2]青岛大学医学院附属医院口腔科,山东青岛266000

出　　处：《华西口腔医学杂志》2008年第1期53-55,共3页West China Journal of Stomatology

摘　　要：目的通过评价3种常用排龈药物引起牙龈炎症程度的大小,为临床选择最佳的排龈药物提供参考。方法将40颗上颌第一前磨牙按随机区组设计分为4组:硫酸铁组、氯化铝组、肾上腺素组、生理盐水组(对照组),每组10颗牙齿,分别采用体积分数为25%氯化铝、15.5%硫酸铁、0.1%盐酸肾上腺素、生理盐水作为排龈药物,于排龈前及排龈后1、3、5、7、9d测定龈沟液中龈沟液(GCF)量和天冬氨酸转氨酶(AST)活性的水平,计算排龈前后GCF变化量。结果排龈后,GCF变化量从小到大依次为生理盐水组、肾上腺素组、氯化铝组、硫酸铁组。肾上腺素组在排龈后第1、3天龈沟液中AST水平与排龈前基值具有统计学差异(P<0.05),硫酸铁组及氯化铝组在排龈后第1、3、5天龈沟液中AST水平与排龈前基值具有统计学差异(P<0.05);与生理盐水组相比,只有硫酸铁组排龈后第1、3天龈沟液中AST水平具有统计学差异(P<0.05)。结论对健康成人的口腔固定修复患者,推荐使用体积分数为0.1%肾上腺素作为排龈药物;对伴有心血管系统疾病的口腔固定修复患者,体积分数为25%氯化铝可作为0.1%肾上腺素的替代排龈药物;硫酸铁需降低体积分数才能临床应用。Objective To choose the best retraction agent for the clinic by evaluating the gingival inflammation related to three kinds of retraction agents. Methods 40 maxillary premolars were divided into four groups according to the randomized block design： Ferric sulfate group, aluminum chloride group, epinephrine group, sodium chloride group（control group）, each 10 teeth, respectively used 25% AlCl3, 15.5% Fe2CSO4）3, 0.1% HCl-epinephrine, sodium chloride as retraction agents. The quantity of gingival crevicular fluid （GCF） and the active level of aspartate aminotransferase （AST） in gingival crevicular fluid were measured before and 1, 3, 5, 7, 9 days after retracting gingiva by four kinds retraction agents. The changes of GCF were calculated. Results The change of the GCF from the smallest to the largest was sodium chloride, 0.1% HCl-epinephrine, 25% AlCl3, 15.5% Fe2CSO4）3. Compared with sodium chloride, only 15.5% Fe2（SO4）3 in AST was the significant difference in the first day and the third day（P〈 0.05）. AST of ferric sulfate group after 1, 3 days greater than 800 IU. Conclusion 0.1% HCl-epinephrine is suggested in patient without cardiovascular disease. For patient with cardiovascular disease, the better substitute is 25% AlCl3, 15.5% Fe2（SO4）3 will not be used until its concentration is fallen.

关 键 词：排龈药物 龈沟液 龈炎 天冬氨酸转氨酶 

分 类 号：R781.4[医药卫生—口腔医学]