心血管ATP敏感钾通道及其相关药物研发  

Cardiovascular Adenosine Triphosphate-sensitive Potassium (K_(ATP)) Channels and Development of Specific Drugs

作　　者：杨莹莹[1] 于锋[1] 

机构地区：[1]中国药科大学临床药学教研室,江苏南京210009

出　　处：《药学进展》2008年第3期110-115,共6页Progress in Pharmaceutical Sciences

基　　金：国家自然科学基金资助项目(30572193);高等学校博士学科点专项科研基金资助项目(20050316009)

摘　　要：综述心肌、血管平滑肌及血管内皮中ATP敏感性钾通道的结构、功能和药理学特性,并展望了ATP敏感性钾通道特异性开放剂和阻断剂的应用前景及该类新药的研究方向。ATP敏感性钾通道是由细胞内ATP调节的一种钾离子通道,不同组织中ATP敏感性钾通道的结构、功能和药理学性质有所不同。Adenosine triphosphate-sensitive potassium （KATp） channels are thought to mediate the stress response by sensing intracellular ATP concentration. KATP in different tissue has different structures, functions and pharmacological character. In this paper, the structure, function and pharmacological character of cardiovascular KATP were briefly summarized. And the prospect of the application of KATP channel opener and KATP channel blocker and the trend of new drug research were discussed.

关 键 词：ATP敏感性钾通道 功能特性 药物研发 

分 类 号：R972[医药卫生—药品]