^99Tc^m-MIBI SPECT预测小细胞肺癌CE方案化疗疗效的临床研究  

^(99)Tc^m-MIBI SPECT in prediction of prognosis in patients with small cell lung cancer treated with chemotherapy of CE

作　　者：张英[1] 刘海峰[2] 张长明[3] 张玉芳[3] 

机构地区：[1]青岛大学医学院核医学科,山东青岛266021 [2]青岛大学医学院呼吸内科,山东青岛266021 [3]聊城市人民医院核医学科,山东聊城252000

出　　处：《中华肿瘤防治杂志》2008年第4期286-288,共3页Chinese Journal of Cancer Prevention and Treatment

摘　　要：目的:探讨99Tcm-MIBI摄取与小细胞肺癌(SCLC)CE方案化疗疗效的关系。方法:48例SCLC患者根据胸部CT分为化疗有效组(完全缓解+部分缓解)和无效组(进展加重+无缓解),于化疗前行99Tcm-MIBI肺显像,静脉注射99Tcm-MIBI740MBq后10～30min及2～3h分别行早期及延迟显像,在99Tcm-MIBI显像的断层图上用感兴趣区(ROI)的方法,勾画出病灶,然后镜像ROI于健侧肺的相应部位,由此分别获得早期相肿瘤/正常肺组织摄取比值(ER)和延迟相肿瘤/正常肺摄取比值(DR),并计算出滞留指数(RI%)=100×(DR-ER)/ER。分析化疗有效组与化疗无效组ER、DR和RI之间的差别。结果:99Tcm-MIBI显像结果中,化疗有效组和无效组平均ER、DR和RI比较差异有统计学意义(t=2.5738,P<0.02;t=4.8291,P<0.001;t=4.7331,P<0.001),化疗有效组的ER、DR、RI均高于无效组。结论:99Tcm-MIBI显像的ER、DR和RI可能有助于预测SCLC患者CE方案化疗的疗效。OBJECTIVE： To explore whether the degree of ^99Tc^m-MIBI uptake in small cell lung cancer （SCLC） treated with chemotherapy of CE is correlated with the response to chemotherapy. METHODS： Forty-eight patients with SCLC were studied with MIBI SPECT before chemotherapy. The patients were classified by a follow-up CT as good responders （complete or partial remission） and poor responders （stable disease or progressive disease）. Following i.v. administration of 740 MBq ^99Tc^m-MIBI, SPECT imagings at 10--30 minutes （early） and 2--3 hours （delayed） were performed. Regions of interests were placed over the tumors and contralateral normal lung tissue on one transverse section. The uptake ratio of the lesion to that in the contralateral normal lung was obtained from early images （ER） as well as delayed images （DR）. The retention index （RI） was measured as： RI= 100 × （DR- ER）/ ER. ^99Tc^m-MIBI tumor uptake parameters were compared with the chemotherapeutic response. RESULTS： ER,DR and RI of ^99Tc^m-MIBI SPECT in the group with good response were significantly higher than in the one with poor response （t=2. 573 8,P〈 0.02;t=4. 829 1,P〈0.001,t=4.733 1, P〈0. 001）. CONLUSION： ER,DR and RI of ^99Tc^m-MIBI SPECT may benefit to predicting the chemotherapy response in patients with SCLC treated with chemotherapy of CE.

关 键 词：癌 小细胞肺/药物疗法 ^99锝^m甲氧基异丁基异腈 抗药性 多药 

分 类 号：R734.2[医药卫生—肿瘤]