多西紫杉醇联合奥沙利铂治疗晚期非小细胞肺癌的临床观察  

Clinical study of docetaxel injection combined with oxaliplatin in advanced non-small cell lung cancer

作　　者：李海金[1] 李文华[1] 郭林琅[1] 董良[1] 李英[1] 符淑媛[1] 

机构地区：[1]中国医科大学华宇医院肿瘤内科,浙江绍兴312030

出　　处：《中华肿瘤防治杂志》2008年第4期296-298,共3页Chinese Journal of Cancer Prevention and Treatment

摘　　要：目的：研究多西紫杉醇加奥沙利铂治疗晚期非小细胞肺癌（non-small cell lung cancer，NSCLC）的近期疗效、毒副反应及神经毒性。方法：96例晚期NSCLC随机分为两组。治疗组49例，多西紫杉醇75mg／m^2静脉滴入，d1；奥沙利铂130mg／m^2，静脉滴入，d2；每3周重复疗程。对照组47例，多西紫杉醇用法及用量同治疗组，顺铂25mg／m^2，静脉滴入，d2～d4，每3周重复疗程。分别评价近期疗效、KPS评分变化、中位生存期、1年生存率、不良反应和神经毒性。结果：治疗组与对照组近期有效率分别为38．78％和36．17％，P=0．788，KPS评分改善率分别为48．98％和34．05％，P=0．138，中位生存期分别为11．5个月和10．3个月，1年生存率分别为42．86％和40．43％（P=0．809），神经毒性发生率分别为20．41％和23．40％，P=0．706；其他不良反应包括中性粒细胞减少、恶心呕吐及疲劳等，治疗组明显低于对照组，P〈O．001。结论：多西紫杉醇加奥沙利铂治疗晚期NSCLC相比多西紫杉醇加顺铂方案疗效相似，但不良反应减少。多西紫杉醇可以明显减轻奥沙刹铂的神经毒性。OBJECTIVE： To evaluate the effect, toxicity and neurotoxicity of docetaxel injection combined with oxaliplatin in the treatment of advanced non-small cell lung cancer（NSCLC）. METHODS： A total of 96 patients with advanced NSCLC were randomized into 2 groups： the treatment group （49 cases） treated with docetaxel 75 mg/m^2 on day 1 and oxaliplatin 130 mg/m^2 on day 2, and the control group （47 cases） was treated with docetaxel 75 mg/m^2 on day 1 and cisplatin 25 mg/m^2 on day 2-4. Both of them were repeated every 21 days. The evaluation of the short-term effect, kanofsky score, the median survival time, 1-year survival rate, toxicity and neurotoxicity was performed after the chemotherapy regularly. RESULTS： The short-term response rates of the treatment group and the control group were 38.78% and 36.17% （P= 0. 788）, respectively, the kanofsky score increasing rates of them were 48.98% and 34.05% （P=0.379）, the median survival time was 11.5 months and 10.3 months, 1-year survival rates were 42.86% and 40.43% （P=0. 809）, and the incidence rates of neurotoxicity were 20.41% and 23.40% （P= 0. 706）, respectively. The incidence rates of other toxicities including leukopenia, nausea, vomiting, and fatigue were lower in the treatment group than in the control group. CONCLUSION： The regimen of docetaxel injection combined with oxaliplatin has the similar efficacy and less toxicities as compared to docetaxel combined with cisplatin in the treatment of advanced NSCLC, and decetaxel can alleviate the neurotoxicity of oxaliplatin obviously.

关 键 词：癌 非小细胞肺 多西紫杉醇 奥沙利铂 药物疗法 联合 神经毒性 

分 类 号：R734.2[医药卫生—肿瘤]