MK因子在不同病理类型宫颈癌组织的表达及临床意义  

The expression of midkine factor and the clinical significance in different categories of pathology in cervical cancer

作　　者：王耀先[1] 于辉[1] 陈秀玮[1] 娄阁[1] 

机构地区：[1]哈尔滨医科大学附属肿瘤医院妇科,哈尔滨150081

出　　处：《现代妇产科进展》2008年第2期92-94,98,共4页Progress in Obstetrics and Gynecology

基　　金：黑龙江省自然科学基金资助项目(No:D2005-48)

摘　　要：目的：探讨MK因子（中期因子）在宫颈癌的表达与临床病理特征的关系。方法：用免疫组织化学法（SP法）检测178例宫颈癌组织和74例宫颈上皮内瘤变组织中MK因子的表达。结果：178例宫颈癌组织中，MK蛋白阳性表达率为91．57％，明显高于宫颈上皮内瘤样病变组织的14．86％（P〈0．001）。宫颈癌临床分期不同MK蛋白阳性表达率不同，临床Ⅰ期阳性表达率显著低于临床Ⅱ～Ⅳ期（P〈0．001）。宫颈鳞癌MK阳性表达率显著高于腺癌（P〈0．001），但与组织分化程度无关（P=0．123）。有盆腔淋巴结转移者MK阳性表达率显著高于无盆腔淋巴结转移者（P=0．026）。结论：MK因子阳性表达与宫颈癌病理特征关系密切，可能成为一种有价值的肿瘤标志物，对宫颈癌的早期诊断及治疗有一定的临床指导意义。Objective： To investigate the relationship between the expression of midkine （MK） factor and characters of clinical pathology in cervical cancer. Methods：The expression of MK was detected by immunohistochemistry in 178 cervical cancer specimens and 74 cervical intraepithelial neoplasia specimens. Results：The positive expression rates of MK were 91.57% and 14.86% for cervical cancer and cervical intraepithelial neoplasia, respectively. The significance different was observed between cervical cancer and cervical intraepithelial neoplasia （P 〈 0.001 ）. The positive exprezsion rates were different among clinical stages. The positive expression rate in clinical stage I was significantly lower than that in clinical stage Ⅱ- Ⅳ （ P 〈 0. 001 ）. The positive expression rate in squamous carcinoma was higher than that in adenocarcinoma（ P 〈 0.001 ）. But the significance different was not found among degrees of histodifferentiation（ P = 0. 123 ）. The positive expression rate was significantly higher in the patients with metastasis to celiac lymph nodes than that of without （ P = 0.026）. Conclusion： There was a closely relationship between the positive expression of MK and character of clinical pathology in cervical cancer and it may be used as a kind of worthy tumor markers.

关 键 词：MK因子 宫颈肿瘤 宫颈上皮内瘤样病变 病理学 临床 免疫组织化学 

分 类 号：R737.33[医药卫生—肿瘤]