乳腺浸润性导管癌中OGF OGFR的表达研究  

The Expression of OGF and OGFR in Invasive Ductal Carcinoma of the Breast

作　　者：胡建功[1] 金小萍[2] 谢朝辉 邢恩鸿[2] 张祥宏[1] 

机构地区：[1]河北医科大学研究生院,石家庄市050017 [2]承德医学院附属医院病理科 [3]河北省承德市肿瘤医院

出　　处：《中国肿瘤临床》2008年第6期336-338,343,共4页Chinese Journal of Clinical Oncology

摘　　要：目的:探讨乳腺浸润性导管癌中OGF、OGFR的表达意义。方法:采用免疫组化SP法检测18例正常乳腺、12例乳腺腺病、8例乳腺异型上皮增生、21例浸润性导管癌组织中OGF、OGFR的表达。结果:在正常乳腺组、乳腺腺病组、乳腺异型上皮增生组、浸润性导管癌组中OGF表达率分别为55.43%、43.48%、34.50%、13.29%,各组间差异有统计学意义(P<0.01);OGFR表达率分别为68.80%、44.22%、40.00%、25.52%,各组间差异有统计学意义(P<0.01)。结论:乳腺组织中可能存在着OGF-OGFR的相互作用;OGF、OGFR的表达减少,减弱了OGF-OGFR的相互作用,可能促进了乳腺癌的发生、发展。增加OGF、OGFR的表达,促进两者的相互作用,可能对乳腺癌的治疗起着重要作用。Objective： To investigate the expression of OGF and OGFR in invasive duetal carcinoma of the breast. Methods： We used immunohistochemistry to detect the expression of OGF and OGFR in 18 samples of normal breast tissue. 12 samples of adenosis, 8 samples of atypical duetal hyperplasia and 21 samples of invasive ductal carcinoma of the breast. Results： The expression rates of OGF in these four kinds of tissues were 55.43%, 43.48%, 34.50%, and 13.29%, respee, tively （P〈0.001）. The expression rates of OGFR in these four kinds of tissues were 68.80%, 44.22%, 40.00%, and 25.52%, respectively （P〈0.001）. Conclusion： There may exist OGF-OGFR interaction in the breast tissue. The decrease in the expression of OGF and OGFR may reduce the timetion of the OGF-OGFR axis in maintaining cell proliferation and may contribute tn the ueeurrenee and development of breast carcinoma. To increase the expression of OGF and OGFR, enhancing OGF-OGFH interaction could be a useful treatment for breast tumor progression.

关 键 词：乳腺浸润性导管癌 免疫组化SP法 相互作用 正常乳腺 上皮增生 乳腺腺病 乳腺组织 表达减少 

分 类 号：R737.9[医药卫生—肿瘤] R735.2[医药卫生—临床医学]