心脏β肾上腺素受体及其亚型随年龄而变化  

ALTERATION OF CARDIAC β-ADRENOCEPTORS AND SUBTYPES WITH INCREASING AGE

作　　者：李艳芳[1] 张幼恰 易永梅[1] 韩启德[1] 

机构地区：[1]北京医科大学第三医院血管医学研究所,北京100083

出　　处：《生理学报》1997年第3期281-284,共4页Acta Physiologica Sinica

基　　金：国家自然科学基金!39370299;39470806;美国中华医学基金!93-591

摘　　要：本文采用放射配体结合实验和离体左心房收缩功能实验观察了48周龄和10周龄Wistar大鼠心脏β肾上腺素受体（β-AR）及其工型的数量和功能的改变。结果表明：（1）心脏β-AR总数量在48周龄人鼠较10周龄大鼠下调约28％，目为β1与β2-AR同等程度下调；（2）48周龄大鼠卜β-AR及其业型对异丙肾上腺素的敏感性明显减弱；（3）在10周龄大鼠心脏介导收缩效应以β1-AR的作用为主，而在48周龄大鼠心脏引起收缩效应则是β1-和β2-AR作用相等；（4）心脏β1-和β2-AR同时激动介寻左心房正性变力效应时，在10周龄大鼠为两种亚型受体效应的正协同，而48周龄大鼠则为两种亚型受体效应的相加。The alteration of cardiac β-adrenoceptor(β-AR) and subtypes in Wistar rats of 48and 10 weeks old were investigated by radioligand binding assay and functional determination of isolated perfused left atria. The results indicated that: (1) The density of cardiac total β-AR was downregulated about 28% in 48 weeks old rats as compared withratS of 10 weeks old for both β1-and β2-AR; (2) The sensitivity of β-AR and subtypesto isoproterenol in isolated perfused atria was significantly lowered in rats of 48 weeksold; (3) The β-AR mediated contractile effect of 10 weeks old rat hearts was mainly attributed to β1 type, but equally to both β1 and β2 types in 48 weeks old rat hearts; (4)The two receptor subtypes showed mutually potentiation effect in 10 weeks old rathearts when stimulated simultaneously, but only additive in 48 weeks old rat hearts.

关 键 词：心脏 Β肾上腺素受体 受体亚型 年龄 

分 类 号：R331.31[医药卫生—人体生理学]