刺激中缝背核对视交叉上核光敏神经元单位放电的影响  

EFFECT OF DORSAL RAPHE NUCLEUS STIMULATION ON UNIT DISCHARGES OF LIGHT-SENSITVE NEURONS OF SUPRACHIASMATIC NUCLEUS IN RATS

作　　者：俞光第[1] 魏晓萍 张惠琴[1] 许爽[1] 印其章[1] 邓柏澧[3] 钱忠明[3] 

机构地区：[1]苏州医学院神经生物学研究室,苏州215007 [2]延安医学院 [3]香港理工大学应用生物化学科技系

出　　处：《生理学报》1997年第3期314-320,共7页Acta Physiologica Sinica

基　　金：国家自然科学基金!39470240

摘　　要：本实验观察刺激中缝背核（DR）对大鼠视交叉上核（SCN）光敏神经元单位放电的影响，并进行药理学分析。结果表明，刺激DR能明显抑制SCN神经元光诱发放电。这种抑制作用能被单胺氧化酶抑制剂优降宁增强，能被5-HT合成抑制剂对氯苯丙氨酸减弱，还能被5-HT受体拮抗剂赛庚啶阻断。结果提示，5-HT参与了刺激DR对SCN光敏神经元放电的抑制。The effect of dorsal raphe nucleus (DR) stimulation on the unit discharge ofsuprachiasmatic nucleus (SCN) neurons was studied and analyzed pharmacologically inthe Wisher rats. Experimental results showed that DR stimulation could significantly inhibit the light-induced discharge of SCN neurons. Pharmacologically, this inhibitioncould be enhanced by monoamine oxidase inhibitor pargyline, attenuated by 5-hydroxytryptamine (5-HT) synthesis inhibitor parachlorphenylalanine and block by 5-HTrecepor antagonist cyproheptadine. It was suggested that the inhibitory effect of DRstimulation on the light-sensitive SCN neuron discharge might be mediated by 5-HT.

关 键 词：丘脑 视交叉上核 中缝背核 光敏神经元 单位放电 

分 类 号：R338.24[医药卫生—人体生理学]