色谱指纹图谱与中药质量控制  

Chromatographic fingerprint and quality control of traditional Chinese medicines

作　　者：易伦朝[1] 吴海[1] 梁逸曾[1] 

机构地区：[1]中南大学化学化工学院中药现代化研究中心,湖南长沙410083

出　　处：《色谱》2008年第2期166-171,共6页Chinese Journal of Chromatography

基　　金：国际科技合作项目(No.2006DFA41090)

摘　　要：本文综述了近年来色谱指纹图谱研究中多种色谱技术、相关化学计量学方法的发展及其在中药质量控制中的应用,并对中药质量稳定性和有效性的全面评价方法和可行性进行了初步探讨。提出以色谱指纹图谱为核心,依托现代色谱技术、化学计量学和系统生物学方法,建立中药化学成分信息与药效(毒性)信息相关关系的中药质量控制研究策略,深层次揭示中药的内在作用机理,期望真正实现中药质量的可控、安全和有效。The development of modern chromatographic technologies and related chemometric methods in the research of chromatographic fingerprint,and their applications in quality control of traditional Chinese medicines（TCMs）are comprehensively reviewed.Furthermore,we preliminarily discuss the quality control methods and their feasibility to guarantee that the TCMs can be used stably and effectively.A new strategy is proposed to establish the comprehensive relationships between chromatographic fingerprints and their pharmacodynamic（toxicity）information with the help of the techniques of modern chromatography,chemometrics and system biology to reveal the working mechanism of TCMs and then to comprehensively control the quality of TCMs.

关 键 词：中药 质量控制 色谱指纹图谱 化学计量学 系统生物学 

分 类 号：O658[理学—分析化学]