酶法D-对羟基苯甘氨酸合成邓氏钾盐工艺探讨  

Investigation in Synthesis of Dane Salt from D-p-hydroxyphenylglycine which is Produced in Enzymatic Process

作　　者：戴连科 许重阳 胡重浩 

机构地区：[1]浙江海正药业股份有限公司,浙江台州318000

出　　处：《浙江化工》2008年第3期10-11,14,共3页Zhejiang Chemical Industry

摘　　要：D-对羟基苯甘氨酸邓氏钾盐是合成阿莫西林的侧链,作为其主要原料的D-对羟基苯甘氨酸有合成法和酶法二种生产工艺,本文对酶法生产的D-对羟基苯甘氨酸的后续产品的质量问题进行了分析并提出了解决方法。Dane salt of D-p-hydroxyphenylglycine is the side chain of amoxillin.It＇s raw material, D-p- hydroxyphenylglycine,can be produced on enzymatic route or by chemical process.This paper analysed the qualitative problem of the Dane salt of D-p-hydroxyphenylglycine which is produced on enzymatic route and put forward a resolution in resolving this problem.

关 键 词：D-对羟基苯甘氨酸邓氏钾盐 D-对羟基苯甘氨酸 合成 酶法 

分 类 号：TQ463.2[化学工程—制药化工]