梗阻性黄疸时胃α_1肾上腺素能受体的密度变化  

STUDY ON DENSE CHANGE OF GASTRIC α_1 ADRENOCEPTOR IN OBSTRUCTIVE JAUNDICE

作　　者：李晓强[1] 杨乃众[1] 李占文[1] 杜如昱[1] 刘鼎新 孟书聪 

机构地区：[1]北京医科大学人民医院外科,100044 [2]北京医科大学人民医院细胞生物学教研室,100044

出　　处：《北京医科大学学报》1997年第5期454-455,458,共3页Journal of Peking University(Health Sciences)

摘　　要：目的：研究大鼠α1肾上腺素能受体在胃粘膜和粘膜下层的分布和梗阻性黄疸时密度的变化。方法：16只Wistar大鼠分成正常组与黄阻性黄疸组，每组8只。并采用光学显微镜放射自显影术。结果：大鼠胃粘膜无α1肾上腺素能受体。α1肾上腺素能受体分布在胃粘膜下层动脉平滑肌细胞表面。正常大鼠α1肾上腺素能受体密度在胃体大干胃窦，梗阻性黄疸时α1肾上腺素能受体密度明显减少。结论：由于α1肾上腺素能受体密度在胃体大于胃窦，所以交感-肾上腺素系统对胃体血流的影响大于胃窦。梗阻性黄疸α1肾上腺素能受体明显减少。Objective: Study on location and dense change of α1 adrenoceptor in gastric mucosa and submucosal artery in obstructive jaundice in rats. Methods: Light microscopic autoradiography. Results: There was not α1 adrenoceptor in gastric mucosa. It was distributed in submucosal smooth muscle. The density of α1 adrenoceptor was more in gastric corpora than that in gastric antrum in normal rats. The density of α1 adrenoceptor was decreased in obstructive jaundice. Conclusion: Because the density of α1 adrenoceptor was more in gastric corpora than that in antrum, effect of sympat het ic-epinephrine system on gastric mucosal blood flow was more apparent in corpus than that in antrum. When density of α1 adrenoceptor was decreased in obstructive jaundice, it rnight be a cause that vascularity in gastric submucosa was not sensitive to norpinephrine.

关 键 词：梗阻性黄疸 胃粘膜 肾上腺素能Α1 

分 类 号：R575[医药卫生—消化系统]