TFPI-2基因与消化道肿瘤关系的研究进展  

Progress of TFPI-2 gene in alimentary canal tumors

作　　者：孙振阳[1] 汤志刚[1] 

机构地区：[1]安徽医科大学附属安徽省立医院普通外科,安徽合肥230001

出　　处：《中华肿瘤防治杂志》2008年第3期227-230,共4页Chinese Journal of Cancer Prevention and Treatment

基　　金：安徽省自然科学基金项目(050430702)

摘　　要：组织因子途径抑制物2(tissue factor path-way inhibitor2,TFPI-2)是一种广谱的丝氨酸蛋白酶抑制物,可抑制包括纤溶酶、胰蛋白酶、基质金属蛋白酶(matrix metalloproteinases,MMPs)在内的多种蛋白酶,而MMPs参与了细胞外基质的重塑,在肿瘤细胞的浸润和转移、伤口愈合、血管新生、纤维蛋白溶解及动脉粥样硬化等生理和病理过程中发挥重要作用。TFPI-2可通过维持细胞外基质的完整、调节肿瘤血管生成、调控肿瘤细胞细胞凋亡及血液凝固等机制调节胰腺癌、食管癌及胃癌等消化道肿瘤细胞的侵袭转移。越来越多的研究表明,TFPI-2能明显抑制肿瘤中MMPs的活性与功能等从而抑制肿瘤的侵袭与转移,并成为肿瘤基因治疗的新靶点。Tissue factor pathway inhibitor 2 （TFPk2） is a broad-spectrum inhibitor of serine proteinase that inhibits plasmin, trypsin and matrix metalloprotei- nases （MMPs）. MMPs plays an important part in tumor invasion and metastasis, intention, angio-neogenesis, fibrinolysis and artherosclerosis. TFPI-2 can maintain the integrity of extracellular matrix, regulate the angiogenesis and apoptosis of tumor cells and thrombokinesis to accommodate the invasion and metastasis of pancreatic cancer, esophageal carcinoma and gastric cancer and so on. More and more studies show that TFPI-2 can inhibit the activity and function of MMPs to inhibit tumor invasion and metastasis. It has been the new target for gene therapy of tumors.

关 键 词：腹部肿瘤 糖蛋白类 综述文献 

分 类 号：R735[医药卫生—肿瘤]