p33^(ING1)在结直肠癌中的表达及其临床意义  

Expression of p33^(ING1) in colorectal carcinomas and its clinical significance

作　　者：贾建光[1] 钱军肿 承泽农[3] 

机构地区：[1]蚌埠医学院第一附属医院急诊外科,安徽蚌埠233004 [2]蚌埠医学院第一附属医院瘤外科,安徽蚌埠233004 [3]蚌埠医学院第一附属医院临床病理科,安徽蚌埠233004

出　　处：《蚌埠医学院学报》2008年第2期138-140,F0004,共4页Journal of Bengbu Medical College

摘　　要：目的:探讨生长抑制基因(inhibitor of growth,p33ING1)在结直肠癌中的表达意义,以及p33ING1与结直肠癌临床病理特征的关系及其可能的作用机制。方法:对60例结直肠癌组织及20例癌旁非肿瘤组织标本,应用免疫组化检测肿瘤组织和正常组织的p33ING1、p21WAF1的表达。结果:p33ING1在结直肠癌组织中的表达阳性率为43.3%,在正常组织中为90.0%,显著低于正常组织(P<0.005);p33ING1减低与结直肠癌的Dukes分期及淋巴结转移有一定关系(P<0.005和P<0.01),而与患者的性别、年龄、肿瘤分化程度、肿瘤部位及浸润深度无明显关系(P>0.05)。p33ING1与p21WAF1表达呈正相关关系(P<0.05)。结论:p33ING1在结直肠癌组织中低表达,对结直肠癌的发生、发展可能起着重要的作用;p33ING1、p21WAF1表达可作为判断结直肠癌恶性程度的重要指标之一。Objective：To explore the expression of p33^ING1 in colorectal cancer and its correlation between the clinic pathological features and the possible mechanism of p33^ING1 in the oncogenesis of colorectal neoplasms. Methods：Sixty histological verified coloreetal carcinomas and twenty neighboring no cancerous tissues were obtained. Immunohistochemistry staining was used to detect p33^ING1 and p21^WAF expression in colorectal carcinomas and normal tissues. Results： p33^ING1 expression were detected in 26 of 60 （43.3%）in colorectal carcinoma,and p33^ING1 expression were detected in 18 of 20 （90.0%）in neighboring no cancerous tissues; A significant decrease in p33^ING1 expression was found in colorectal carcinomas （ P 〈 0. 005 ）. The result also showed that expression of p33^ING1 markedly related to both the Dukes classification and metastasis（ P 〈 0.005 and P 〈 0.01 ） ;and was not related to patient＇ s sex, age, tumor differentiation, site and tumor growth （P 〉 0.05 ）. The relationship between p33^ING1 and p21^WAF was positive correlation （P 〈 0.05 ）. Conclusions：p33^ING1 expression in colorectal carcinoma is low, and plays an important role in the colorectal carcinogenesis and development. The p33^ING1 and p21^WAF expression can be used as one of the important indicators for level of malignancy in colorectal carcinomas.

关 键 词：结直肠肿瘤 免疫组织化学 腺癌 P33^ING1 p21^WAF 

分 类 号：R735.3[医药卫生—肿瘤] R392.31[医药卫生—临床医学]