肝硬化患者血清及腹水CA125水平的临床意义(附78例资料分析)  

Clinical elevation of serum and ascites CA125 Levels in liver cirrhosis.

作　　者：汪明涛[1] 陈范嵘[1] 郭继兵[1] 李晓红[1] 朱春燕[1] 

机构地区：[1]上海市普陀区人民医院消化科

出　　处：《华中医学杂志》2007年第6期479-480,共2页Central China Medical Journal

摘　　要：目的探讨肝硬化患者血清和腹水CA125浓度的变化与肝功能Child-pugh分级的关系。方法肝硬化78例,其中肝硬化无腹水21例,肝硬化伴腹水57例,正常对照组35例,检测所有患者及正常对照组血清CA125,其中肝硬化伴腹水患者同时检测血清及腹水CA125,并与Child-pugh分级指标做相关分析。结果肝硬化组血清CA125水平极显著高于对照组(P<0.01),肝硬化血清CA125水平Child-pughC级>B级>A级,随着肝功能损害程度加重而进行性升高(P<0.01)。结论肝硬化患者血清CA125水平与肝功能损害程度及腹水存在有关,可被认为是反映肝硬化程度及监测腹水情况的一项敏感指标。Objective To study the relationship between serum and ascites CA125 levels and Child-pugh classiticauon of liver cirrhosis. Methods A total of 78 patients and 35 normal persons were studied, Group Ⅰ consisted of 21 cirrhotic patients without ascites. Group Ⅱ consisted of 57 patients with cirrhosis and ascites, Group Ⅲ consisted of 35 cases of normal controls. CA125 levels were measured in serum of 78 patients and also simultaneously in ascitic fluids of 57 patients. Results The levels of serum CA125 in liver cirrhosis patients were significantiy higher than in control（P〈0. 01）and in Child-pugh C higher than B, and Child-pugh B higher than A. increased with aggravating lesion of the liver（P〈0. 01）. Conclusion The levels of serum CA125 in liver cirrhosis patients were osculantly correlative with lesion of the liver and ascites degree, could serve as a sencitve marker for liver lesion degree and monitoring ascites quantity.

关 键 词：肝硬化 血清糖类抗原125 CHILD-PUGH分级 

分 类 号：R575.2[医药卫生—消化系统]