缺氧诱导因子和细胞黏附分子在胰腺癌中表达及临床意义  

The expressions of hypoxia-inducible factor-1α and cell adhesion molecules in pancreatic adenocarcinoma and their clinical significance

作　　者：高臻[1] 柴小军[1] 孙红成[1] 裘正军[1] 

机构地区：[1]上海交通大学附属第一人民医院普外科,上海200080

出　　处：《肿瘤》2008年第3期256-259,共4页Tumor

摘　　要：目的:了解胰腺癌中缺氧诱导因子-1α(hypoxia-inducible factor-1α,HIF-1α)与E-钙黏素(E-cadherin)、整合素β1(in-tegrinβ1)的表达关系,探讨HIF-1α促进胰腺癌侵袭转移的机制及临床意义。方法:用免疫组织化学法检测34例胰腺癌和10例正常胰腺组织中HIF-1α、E-cadherin和integrinβ1的表达,分析HIF-1α和E-cadherin、integrinβ1的表达之间的相关性及与临床病理特征的关系。结果:胰腺癌组织存在HIF-1α过表达、E-cadherin异常表达和integrinβ1高表达。HIF-1α与E-cad-herin的表达呈负相关,与integrinβ1无关;HIF-1α表达与病理分期、淋巴转移有关,E-cadherin异常表达与肿瘤分化、病理分期和淋巴转移有关,integinβ1与临床病理特征无关。结论:HIF-1α可能通过调节E-cadherin异常表达促进胰腺癌侵袭转移,免疫组织化学检测HIF-1α和E-cadherin对判断胰腺癌恶性潜能可能有一定的价值。Objective： To investigate the relationship between the expressions of hypoxia inducible factor-1α（HIF-1α） and cellular adhesion molecules in human pancreatic adenocarcinoma, and discuss the mechanism for the promoting effects of HIF-1α on cancer invasiveness and metastasis and the clinical significance. Methods：Expressions of HIF-1α, E-cadherin and integrin β1 were detected by immunohistochemistry in 34 cases of radically resected pancreatic cancer tissues and 10 normal pancreatic tissues. The association of the expression of HIF-1α with the expression of E-cadherin and integrin β1 and the relationship be- tween expression of HIF-1α and clinical features were analyzed. Results-There were overexpressions of HIF-1α, abnormal expression of E-cadherin, and high expression of integrin in pancreatic cancer tissues. Expression of HIF-1α negatively correlated with E-cadherin but had no significant relationship with expression of integrin. Expression of HIF-1α correlated with pathological staging and lymph node metastasis. Abnormal expression of E-cadherin was associated with tumor differentiation, pathological staging, and lymph node metastasis. Expression of integrin had no correlation with clinical features. Conclusion： HIF-1α promotes cancer invasiveness and metastasis by regulating abnormal expression of E-cadherin. Immunhistochemistry results indicated that detection of HIF-1α and E-cadherin may be valuable for judging the potential malignancy of pancreatic cancer.

关 键 词：胰腺肿瘤 缺氧诱导因子-1 Α亚基 E-钙黏素 抗原 CD 29 免疫组织化学 

分 类 号：R735.9[医药卫生—肿瘤]