皮肤癌组织中激酶抑制蛋白-1和周期素D1的表达  

Expression of P27^(kip1) and Cyclin D1 in cutaneous carcinoma tissue

作　　者：郝媛媛[1] 刘林嶓[1] 

机构地区：[1]郑州大学第一附属医院整形外科,郑州45005

出　　处：《郑州大学学报（医学版）》2008年第2期215-217,共3页Journal of Zhengzhou University(Medical Sciences)

基　　金：河南省科技攻关基金资助项目0124170636

摘　　要：目的:探讨皮肤基底细胞癌(BCC)及鳞状细胞癌(SCC)组织中激酶抑制蛋白-1(P27kip1)和周期素D1(Cyclin D1)的表达及意义。方法:应用免疫组织化学SP法检测27例BCC、23例SCC和20例正常皮肤组织中P27kip1和Cyclin D1蛋白的表达。结果:BCC和SCC组织中P27kip1表达的阳性率分别为63.0%和26.1%,低于正常皮肤中的95.0%(P<0.05);BCC和SCC组织中Cyclin D1表达的阳性率分别为37.0%和78.3%,高于正常皮肤中的0.0%(P<0.05);在BCC和SCC组织中,P27kip1与CyclinD1的表达相关(P<0.05)。结论:P27kip1异常低表达和Cyclin D1异常高表达可能协同参与BCC和SCC的发生、发展。Aim：To investigate the expression and significance of P27^kip1 and Cyclin D1 protein in cutaneous basal cell carcinoma（BCC） and squamous cell carcinoma（SCC） tissue. Methods：The expressions of P27^kip1 and Cyclin D1 protein were detected by using immunohistochemical SP staining in 27 cases of BCC, 23 cases of SCC and 20 cases of normal skin. Results ：The expressions of P27^kip1 protein in BCC （63.0%） and SCC（26.1% ） were significantly lower than that in normal skin （95.0%） （ P 〈 0.05 ）. The expressions of Cyclin D1 protein in BCC （ 37.0% ） and SCC （ 78.3% ） were significantly higher than that in normal skin（0.0% ） （ P 〈 0.05 ）. In BCC and SCC tissue, P27^kip1 expression was related with Cyclin D1 expression （P 〈 0.05 ）. Conclusion ： The abnormal expression of P27^kip1 and, Cyclin D1 may contribute to the pathogenesis and progression of BCC and SCC.

关 键 词：皮肤肿瘤 基底细胞癌 鳞状细胞癌 激酶抑制蛋白-1 周期素D1 

分 类 号：R739.5[医药卫生—肿瘤]