松果有效成分研究——VI.红松与油松松塔及松子壳的抗癌活性  

Studies on effective compositions of Pine cone Ⅵ. Antitumor activity of fractions from pine cone and pine nut shell of Pinus koraiensis Sieb et Zucc and P.tabulaeformis Carr.

作　　者：吕永俊[1] 王士贤 彭芳[1] 李好枝[1] 刘光明[1] 

机构地区：[1]大理学院药学院,云南大理671000 [2]天津医药研究院肿瘤室,天津300070

出　　处：《大理学院学报（综合版）》2008年第2期1-2,共2页Journal of Dali University

基　　金：国家自然科学基金资助项目(39070886)

摘　　要：目的:研究松塔和松子壳的抗癌活性。方法:采用给小鼠接种肿瘤细胞法测定松塔和松子壳的抗癌活性。结果:从红松松塔的碱性水提取多糖(60mg/kg)CK—C,对S180抑瘤率为48.9%,而CK—DEF对U14的抑瘤率为36.0%和40.4%;对Hep A,CK—DEF作用优于环磷酰胺。结论:松塔和松子壳有效成分具有较好的抗癌作用。Objective：To study the anti-tumor activity of fractions from pine cone and pine nut shell. Methods：The anti-tumor activity of the extract from pine cone and pine nut shell was measured by injecting tumor cells into mice. Results：CK-C of the poly saccharine fractions obtained by NaOH extraction from Pinus Koraiensis Sieb et Zucc showed the most potent anti-tumor activity by 60 mg/kg.d×7 for S180,and the inhibitory rate of tumor was 48.9% ;and CK-DEF was highest for U14,and the inhibitory rate of tumor was 36.0% and 40.4% ;and CK-DEF was better than Cylophamide for Hep A. Conclusion：The activity of fractions from pine cone and pine nut shell showed obvious anti-tumor action.

关 键 词：松果 抗癌活性 S180 U14 HEP A 

分 类 号：R965[医药卫生—药理学]