AML,MAL及RAEB-2中Auer小体检出率及其形态学观察  

Detection Rate and Morphologic Observation of Auer Body in AML,MAL and RAEB-2

作　　者：张明洁[1] 李素君[1] 徐薇[1] 严蜀华[1] 刘蔚[1] 

机构地区：[1]武汉科技大学附属医院检验科,武汉430064

出　　处：《数理医药学杂志》2008年第2期177-178,共2页Journal of Mathematical Medicine

摘　　要：目的:观察急性髓细胞白血病(AML)、急性混合细胞白血病(MAL)及原始细胞过多难治性贫血-2型(RAEB-2)标本中Auer小体的形态及其检出率。方法:瑞-姬氏染色,油镜观察。结果:阳性检出率为39.3%。其中M3的检出率最高,为72.7%,与M5及M6比较有显著差异(P<0.01),而M5中仅见于M5b。观察中发现多种形态的Auer小体并进行了相关组化鉴定。结论:Auer小体的形态是多种多样的,不典形Auer小体的鉴别必须辅以POX及PAS等组化染色。一旦发现Auer小体,即标志为AML、MAL或MDS。Objective： To study the morphology and detection rate of the Auer body of acute myeloid leukemia（AML）, mixed acute leukemia（MAL） and refractory anemia with excess of blasts-2（RAEB-2）. Methotis： Wright-Giemsa stain, study stain with immersion objective. Results： Positive detection rate is 39. %, in which the detection rate of Ms is 72. 7% and is highest, have the remarkable difference comparing with M5 and M6（P〈0. 001）,but in M6 only sees MSb. In the observation, many shapes of Auer body was detected and carried on the related histochemistry analysis. Conclusion： Morphology of Auer bodys are quite different , to identify the atypical form of Auer bodys, it is helpful to consider POX and PAS histochemical stain. Once discovered the Auer body, namely the symbol of AML, MAL or MDS.

关 键 词：急性髓细胞白血病 急性混合细胞白血病 原始细胞过多难治性贫血-2型 AUER小体 

分 类 号：R733.71[医药卫生—肿瘤]