Caspase-3及其底物DFF45在大肠腺癌组织中的表达和意义  

The relationship between Caspase-3 and DFF45 expression in colorectal carcinoma tissue and its clinical significance

作　　者：余昳[1] 田慧军[1] 

机构地区：[1]广州军区武汉总医院老年病一科,湖北武汉430070

出　　处：《现代肿瘤医学》2008年第4期609-611,共3页Journal of Modern Oncology

摘　　要：目的:研究Caspase-3和DFF45在人大肠腺癌组织的表达及与临床病理特征的关系,并探讨其与大肠腺癌的侵袭和转移的关系。方法:采用免疫组织化学S-P法测定58例大肠腺癌组织中Caspase-3和DFF45的表达情况。结果:Caspase-3、DFF45在大肠腺癌中的阳性表达率分别为34.5%(20/58)、46.6%(27/58),Caspase-3、DFF45的表达与分化程度、淋巴结转移有关(P<0.05),而与组织类型、Dukes分期无明显相关(P>0.05)。Caspase-3的表达与DFF45呈显著正相关(r=0.414,P=0.001)。结论:Caspase-3和DFF45蛋白的低表达促进了大肠癌细胞的生长和淋巴结的转移。Objective：To investigate the effect of Caspase -3 and DFF45 protein in the carcinogenesis and progression of human colorectal ad and identify their correlations with the invasion and metastasis of colorectal adenocarcinoma. Methods： The Caspase -3 and DFF45 proteins levels in 58 patients with colorectal carcinoma were detected by means of immunohistochemistry. Results： In 58 cases of colorectal adenocarcinoma,the positive rates of Caspase -3 and DFF45 proteins were 34.5% and 46.6% respectively. The positive expression of Caspase - 3 and DFF45 protein was not associated with the pathological types and Dukes stage （P 〉 0.05 ）, but was highly associated with cellular differentiation degree and lymph node metastasis （P 〈 0.05）. In the 58 cases, a positive correlation was present between Caspase - 3 and DFF45 protein expression （ r = 0. 414, P = 0. 001 ）. Conclusion： The down - regulation of Caspase - 3 and DFF45 may contribute to tumor growth and lymph node metastasis in colorectal adenocarcinoma

关 键 词：大肠癌 CASPASE-3 DFF45 

分 类 号：R735.34[医药卫生—肿瘤]