氯米帕明联合阿立哌唑治疗恶劣心境障碍临床研究  

A clinical study of clomipramine hydrochloride combined with aripiprazole in dysthymia

作　　者：高传伟 

机构地区：[1]商丘市第二人民医院,河南商丘476000

出　　处：《临床心身疾病杂志》2008年第2期117-118,共2页Journal of Clinical Psychosomatic Diseases

摘　　要：目的探讨氯米帕明联合小剂量阿立哌唑治疗恶劣心境障碍患者躯体症状的临床效果。方法将130例恶劣心境障碍患者随机分成两组,研究组74例,口服氯米帕明联合阿立哌唑治疗;对照组56例,单用氯米帕明治疗。观察4w。于治疗前及治疗第4w末采用抑郁自评量表评定抑郁状况,采用自制躯体症状调查表评定躯体症状,对两组评定结果进行对比分析。结果抑郁自评量表评分两组治疗后总粗分均较治疗前显著下降(t=29.51,21.27,P均<0.01),同期两组间比较均无显著性差异(P均>0.05)。治疗4w末,研究组对躯体症状改善的显效率为56.8%、总有效率为97.3%,对照组分别为21.4%、82.1%,研究组均显著高于对照组(χ2=16.40,5.14,P<0.01～0.05)。结论氯米帕明联合小剂量阿立哌唑治疗恶劣心境障碍患者,在改善抑郁症状的同时,还能显著改善患者的躯体症状,有利于提高患者长期治疗的依从性。Objective To explore the curative effectiveness of clompramine combined with low dose of aripiprozole in physical symptoms of patients with dysthymia. Methods 130 patients with dysthymia were randomly assigned to research group（n = 74） taking orally clomipramine plus aripiprazole and control group （n=56） doing single clomipramine for 4 weeks. Depression states were assessed with Self-rating Depressive Scale（SDS） and physical symptoms with Self-made Physical Symptom Queationnaire（SPSQ） before and after 4 week treatment,and evaluation results of the 2 groups compared. Results The SDS scores of both 2 groups lowered more significantly after 4 week treatment compared with pretreatment（both P〈0.01） and there was no significant difference in synchronization intergroup comparison（all P〉0.05）. After 4 week treatment excellence and total rates of physical symptom improvement were respectively 56.8 % and 97.3% in the research group and 21.4% and 82.1% in the control group, which showed that those were significantly higher in the research than in the control group（P〈0.01-0.05）. Conclusion Clomipramine combined with low dose of aripiarazole not only improve depressive symptoms but significantly improve patients＇ physical symptoms and is in favour of raising patients＇ longterm therapy compliance more curative efficacy on the physical symptoms of dysthymia.

关 键 词：恶劣心境障碍 躯体症状 氯米帕明 阿立哌唑 

分 类 号：R749.4[医药卫生—神经病学与精神病学]