HIFU治疗前列腺癌对血清PMSA水平及特异性细胞免疫功能的影响  

Effect of treatment of prostate cancer by HIFU on serum prostate specific membrane antigen and specific cellular immune function

作　　者：骆益宙[1] 廖辉[1] 黄璜[1] 刘曼佳[1] 赵怡[1] 于浩[1] 张一芳[1] 

机构地区：[1]解放军第454医院肿瘤科,江苏南京210002

出　　处：《西南国防医药》2008年第2期172-173,共2页Medical Journal of National Defending Forces in Southwest China

基　　金：南京军区医药卫生科研项目(06MA71)

摘　　要：目的:研究超声聚能刀(HIFU)治疗前列腺癌对血清前列腺特异性膜抗原(PSMA)水平变化及特异性激活细胞毒性T淋巴细胞活性的影响。方法:8例确诊前列腺癌患者,ELISA法检测HIFU治疗前后血清PSMA,混合淋巴细胞反应检测特异性细胞毒性T淋巴细胞的增殖。结果:HIFU治疗后,血清PSMA升高,并可显著刺激特异性T淋巴细胞增殖,与对照组比较具有显著性差异(P<0.01)。结论:HIFU治疗可有效激活机体PSMA特异性的T细胞。Objective investigate the effects of treatment of prostate cancer by high intensity focused ultrasourd（HIFU） on serum prostate specific membrane antigen（PSMA） and activation of cytotoxic T lymphocytes Methods：8 cases of prostate cancer were treated by HIFU. Before and after the treatment, the levels of their serum PSMA were detected by ELISA and the proliferation of specific cytotoxic T lymphocytes was examined by mixed lymphocyte reaction method. Results： After treated by HIFU, the level of PSMA of the patients increased and the proliferation of cytotoxic T lymphocytes was strongly activated. Compared with the control group, the changes of PSMA and proliferation of cytotoxic T lymphocytes were very significan different（P〈0. 01）, Conclusions： HIFU could activate effectively the PSMA specific T lymphocyte.

关 键 词：前列腺肿瘤 超声聚能刀 T细胞特异性免疫 前列腺特异性膜抗原 

分 类 号：R737.25[医药卫生—肿瘤]