奎硫平和利培酮治疗老年期痴呆精神行为障碍的比较研究  

Comparison of efficacy and safety between quetiapine and risperidone in the treatment of senile dementia

作　　者：罗烈岚[1] 沈涌[1] 李桂萍[1] 

机构地区：[1]杭州市第七人民医院老年病科,浙江省杭州市310013

出　　处：《实用老年医学》2008年第2期134-136,共3页Practical Geriatrics

摘　　要：目的探讨奎硫平治疗老年期痴呆精神行为障碍的疗效和安全性。方法将60例老年期痴呆患者随机分为2组,奎硫平组30例,利培酮组30例,分别给予两药治疗8周。采用阳性症状和阴性症状量表(PANSS)评定临床疗效,不良反应量表(TESS)及有关实验室检查评定不良反应。结果治疗8周后两药的疗效近似(P>0·05)。利培酮组锥体外系不良反应和内分泌改变的发生均明显高于奎硫平组(P<0·05)。结论奎硫平治疗老年期痴呆精神行为障碍疗效与利培酮相当,但不良反应较利培酮少,更适用于老年患者。Objective To investigate the clinical efficacy and side effects of quetiapine in the treatment for behavioral and psychiatric symptoms in elderly patients with dementia. Methods Sixty patients with senile dementia were randomly allocated to two groups and were treated with quetiapine or risperidone for eight weeks respectively. The positive and negative syndrom scale（PANSS） and treatment emergent symptoms scale（TESS） were used to evaluate efficacy and adverse effects respectively before and at the end of 2,4,8 weeks of treatment. Results The therapeutic efficacy in quetiapine group was similar to that in risperidone group,there was no significant difference between the two groups（ P 〉 0. 05）. Incidence of adverse effects in quetiapine group was lower than that in risperidone group, but the difference was not significant （P 〉 0.05 ）. The rates of extra-pyramidal symptoms and endocrine change were significantly higher in risperidone group than those in quetiapine group（ P 〈 0. 05 ）. Conclusions Quetiapine is as effective as risperidone for the treatment of senile dementia, with less side effects.

关 键 词：奎硫平 利培酮 老年性痴呆 

分 类 号：R749.16[医药卫生—神经病学与精神病学]