RETREATMENT WITH FLUDARABINE AND CYCLOSPORINE FOR ONE CASE OF REFRACTORY PURE RED CELL APLASIA  

作　　者：Guang-sheng He Xiang Zhang De-pei Wu Ai-ning Sun Miao Miao Xiu-li Wang Zheng-ming Jin 

机构地区：[1]Department of Clinical Hematology, Key Laboratory of Thrombosis and Hemostasis of Ministry of Health, Jiangsu Insititute of Hematology, the First Affiliated Hospital of Soochow University, Suzhou 215006

出　　处：《Chinese Medical Sciences Journal》2008年第1期60-62,共3页中国医学科学杂志（英文版）

基　　金：Supported by the Natural Science Foundation of Jiangsu Province(2004BK424);the 135 Key Department Fund of Jiangsu Province(135XY0416);the Outstanding Person Fund of the First Affiliated Hospital of Soochow University(2004YQG05)

摘　　要：MANY cases of pure red cell aplasia （PRCA） were mediated by over-function of immune cells, and responded well to immunosuppressive therapy. Sometimes refractory cases also arose. Fludarabine is an analogue of adenosine resistant to deamination which is widely used for B-chronic lymphocytic leukemia （CLL） and other hematological malignancies.^2 As a strong immunosuppressive agent, fludarabine has generally been used in nonmyeloblative conditioning regimens for hematopoietic stem cells transplantation for hematological malignancies and severe aplastic anemia recently.^3 In this study,

关 键 词：pure red cell aplasia REFRACTORY FLUDARABINE 

分 类 号：R555[医药卫生—血液循环系统疾病]