慢性精神分裂症血超氧化物歧化酶与精神病理关系研究  

The relationship between blood SOD concentration and psychopathology in chronic schizophrenic patients.

作　　者：张向阳[1] 周东丰[1] 张培琰[2] 苏建民[2] 成秀芳[2] 张华远[2] 赵玉华 南振国[2] 崔勇[2] 刘津[2] 高士元[2] 管振全[1] 朱艺兰 阮燕[1] 孙丽丽[1] 

机构地区：[1]北京医科大学精神卫生研究所,100083 [2]北京回龙观医院

出　　处：《中国神经精神疾病杂志》1997年第4期219-221,共3页Chinese Journal of Nervous and Mental Diseases

摘　　要：目的　探讨自由基及其防御酶超氧化物歧化酶 (SOD)在精神分裂症病理机制中的作用。　　方法　采用放射免疫法测定 66例慢性患者和 2 5例正常人SOD含量 ,同时评定BPRS、SAPS、SANS量表。　　结果　患者SOD含量明显升高 ,其中BPRS、SAPS高分组比低分组的SOD均显著升高 (P <0 0 5) ,SANS高、低分组之间无差异。相关分析结果表明 ,SOD与BPRS、SAPS、SANS量表总分均呈显著正相关 (P <0 0 5)。Objective The purpose of this study was to investigate the relationship between free radical metabolizing enzymes superoxide dismutase (SOD) and psychopathology of schizophrenia. Methods Blood SOD levels were measured in 66 chronic patients who met DSM-Ⅲ - R criteria for schizophrenia and 25 normal controls by using double - antibody immunoradiometric assay. Results Mean blood SOD concentration was significantly higher in schizophrenic patients than in the control subjects( P <0 05). And there was no relationship among SOD levels, the age, gender, and duration of illness. The patients were divided into two subgroups respectively by the average scores of BPRS, SAPS and SANS, blood SOD levels were significantly elevated in patients with higher total scores in comparsion to those with lower scores of BPRS or SAPS, but no significant differences were found between higher and lower SANS scores subgroups. There were significantly positive correlations between SOD levels and the total scores of BPRS or SAPS or SANS( P <0 05). Conclusions Free radicals could be partly associated with the psychopathologic course of schizophrenia.

关 键 词：精神分裂症 超氧化物歧化酶 病理学 

分 类 号：R749.302[医药卫生—神经病学与精神病学]