去甲肾上腺素及拮抗剂、氟哌啶醇对大鼠海马CA_3区双脉冲反应的影响  

Effects of norepinephrine and its antagonists,haloperidol on paired-pulse responses in rat hippocampus CA_3,region in vitro

作　　者：许崇涛[1] 刘协和[1] 吴前[2] 柴慧霞[2] 

机构地区：[1]华西医科大学精神科 [2]华西医科大学生理教研室

出　　处：《中国神经精神疾病杂志》1997年第5期257-260,共4页Chinese Journal of Nervous and Mental Diseases

摘　　要：目的 探讨脑诱发电位P_(50)感觉门控的神经学机制。方法 利用海马脑片技术,研究大鼠海马CA_3区双脉冲反应及药理特性。结果 双脉冲刺激苔藓纤维,可在海马CA_3区观察到长持续抑制(75～750ms),去甲肾上腺素(NE)(10μmol/L)减弱这种抑制。氟哌啶醇(50μmol/L)、酚妥拉明(75μmol/L)可阻断NE的去抑制作用,心得安(20μmol/L)则否,表明NE的去抑制作用与α受体有关。结论 海马CA_3区长持续抑制及药理特性与P_(50)感觉门控相似,提示这种抑制可能是P_(50)感觉门控的基础。Objective To probe the neurological mechanism of the sensory gating expressed by Px of auditory evoked potential. Methods The paired-pulse responses in CA3 region and its pharmacological characteristics were studied in rat hippocam-pal slice in vitro. Results By paired-pulse stimulation on mossy fibers in CA3 region of rat hippocampus, a long-lasting inhibition can be observed and it can be reduced by nore-pinephrine (10 /imol/L). The disinhibitory action of nore-pinephrine can be blocked by haloperidol (50 jumol/L) or phentolamine (75 faneA/L), but not by propranolol (20 jumoL/L), which suggested that the action of norepinephrine involved its activation of a-receptor. Conclusions The similarities between the long - lasting inhibition in CA3 and the sensory gating expressed by Px suggested that the long-lasting inhibition might be the basis of the sensory gating.

关 键 词：精神分裂症 去甲肾上腺素 海马 双脉冲反应 

分 类 号：R749.3[医药卫生—神经病学与精神病学]