磁共振相位对比法对肝硬化门脉血流量的测定  

Quantitative analysis of portal flow of patients with liver cirrhosis

作　　者：武生平[1,2] 李果珍[1,2] 陈彦[1,2] 杨志文[1,2] 褚德发[1,2] 钱蕴华[1,2] 

机构地区：[1]北京医院磁共振室 [2]首钢总医院磁共振室

出　　处：《中华放射学杂志》1997年第10期682-685,共4页Chinese Journal of Radiology

摘　　要：目的：探讨磁共振血流测定在肝硬化病人的临床应用。材料与方法：测量了５６例健康人和６１例肝硬化患者的门脉血流量。肝功能依照Ｃｈｉｌｄ－Ｐｕｇｈ计分法分为三级；用钡餐（全部）和胃镜（１４例）将食管静脉曲张分为轻、中和重度。结果：（１）电影相位对比（ｃｉｎｅＰＣ）法测量的４１例正常人空腹门脉血流量呈正态分布，７５％正常人门脉血流量集中在９．５～１６．０ｍｌ／ｍｉｎｋｇ－１之间。１５例餐后测量均显示流量增加。（２）肝硬化患者空腹门脉流量分布复杂，呈低（１８．３％）、中（３１．７％）、高（５０．０％）分布，另有１例返流。（３）门脉血流量在肝功能各Ｃｈｉｌｄ－Ｐｕｇｈ分级间无统计学意义。（４）门脉流量与食管静脉曲张严重程度相一致，并与曲张出血有关。结论：无创性磁共振技术可以用于肝的生理功能检查；进一步前瞻性研究将对肝硬化的治疗和预后提供有决定意义的信息。Purpose: To evaluate clinical significance of MR quantitative analysis of portal blood flow in liver cirrhosis.Materials and methods:56 normal and 61 liver cirrhosis were scanned and measured.Liver function was graded with Child Pugh score.Esophageal varices was graded. Results: The distribution of flow volume described a normal curve in normal volunteers with 75% in the range of 9.5～ 16.0 ml/min·kg -1 .Food increased the blood flow. The portal venous blood flow of liver cirrhosis was complex, low(18.3%),normal(31.7%) or high(50.0%), and there was a case with reverse flow. No statistically significant difference of portal blood flow was noted in different liver functions by Child Pugh score. The amount of portal blood flow paralleled the severity of esophageal varix. Conclusion:MR portal flow analysis is a noninvasive technique for investigation of liver physiology and prospective study may prove to be of value in planning and prognosis of patients with liver cirrhosis.

关 键 词：磁共振成像 对比分析 肝硬化 门静脉 血液动力学 

分 类 号：R575.204[医药卫生—消化系统]