一例^(192)Ir源辐射事故病人受照生物剂量的估算  

Cytogenetic dosimetry for a victim accidentally exposed to 192 Ir gamma rays.

作　　者：金璀珍[1] 刘秀林[1] 张泽云[1] 

机构地区：[1]北京放射医学研究所

出　　处：《中华放射医学与防护杂志》1997年第1期34-36,共3页Chinese Journal of Radiological Medicine and Protection

摘　　要：目的用染色体畸变分析方法对一例１９２Ｉｒ源辐射事故病人进行生物剂量估计。方法照后７２小时取血培养，分析Ｍ１细胞双着丝粒加环畸变频率作为生物剂量估算依据，并于照后３１天，６６天追踪观察。同时用双＋环畸变在细胞间的泊松分布统计检验，以示照射的均匀性。结果根据照后７２小时双＋环频率估算个体辐射剂量为２．９Ｇｙ，这一剂量与物理方法测定的剂量比较接近，与临床放射损伤的诊断也是一致的。事故后３１，６６天又取血培养，分析双＋环畸变数与照后７２小时差别不大。同时用双＋环畸变数在细胞间的泊松分布统计检验，证实偏离泊松分布。结论这是一例高度不均匀照射病例。Objective Cytogenetic dosimetry was performed for a victim who was over exposed to 192 Ir gamma rays.Methods The individual dose was estimated by the yields of dicentrics plus rings.Results Based on the cytogenetic findings,the equivalent whole body dose was estimated to be 2.9Gy.This dose was in good agreement with the mean dose calculated from physical measurement and conformable to the clinical diagnosis.Follow up studies of chromosome aberrations were carried out 31st and 66th days after the accident.It was shown that the yields of dic+r were reasonably constant.A non Poisson distribution of dic+r and the presence of a few multi aberrant cells were consistent with the non uniform exposure.Conclusion This was a highly inhomogeneously irradiated case.

关 键 词：生物剂量 染色体畸变 ^192IR 放射损伤 

分 类 号：R144.1[医药卫生—公共卫生与预防医学] R818.74