组织学、电镜及免疫组化技术确诊口腔粘膜恶性黑色素瘤的对比研究  

Study on Diagnosis of Oral Mucosal Melanoma with Histology, Electron Microscopy (EM) and Immunohistochemistry

作　　者：王志良[1] 杨连甲[1] 高玉好[1] 董绍忠[1] 

机构地区：[1]第四军医大学口腔医学院病理学教研室

出　　处：《华西口腔医学杂志》1997年第3期223-225,共3页West China Journal of Stomatology

摘　　要：总结了１５例口腔粘膜原发性恶性黑色素瘤，对比研究了Ｆｏｎｔａｎａ染色、电镜观察和免疫组化方法检查在确诊恶性黑色素瘤方面的诊断价值。结果发现，１５例口腔粘膜原发性恶性黑色素瘤中，４例为无色素型黑色素瘤，这４例中Ｆｏｎｔａｎａ染色２例阳性。电镜观察的３例无色素型黑色素瘤，均未发现典型黑色素小体存在。１５例黑色素瘤的抗单克隆抗体染色全部阳性。本研究显示，对Ｆｏｎｔａｎａ染色阴性，可疑为恶性黑色瘤的病例，应做免疫组化染色，进一步确诊。Fifteen cases of primary oral mucosal melanoma were studied with the methods of Fontana Staining, EM, and immunohistochemistry. The results showed that 4 of 15 cases were non pigmented lesions. In these cases, two were positive with Fontana staining. Pigment body could not be found in three cases observed under EM, but all the 15 cases were positive with immunohistochemical staining. The results suggested that the immunohistochemical staining should be done for those cases suspected as non pigment melanoma.

关 键 词：口腔粘膜肿瘤 黑色素瘤 免疫组化 电镜 组织学 

分 类 号：R739.850.4[医药卫生—肿瘤]