轻度低温对大鼠脑缺血损伤的保护作用  

The protective effects of mild hypothermia in cerebral ischemia injury of rats

作　　者：赵玉武[1,2] 郭述苏[1,2] 刘思当[1,2] 曹丙振[1,2] 曹霞[1,2] 

机构地区：[1]济南军区总医院神经内科 [2]山东农业大学动物病理室

出　　处：《临床神经病学杂志》1997年第4期201-203,共3页Journal of Clinical Neurology

摘　　要：本文观察了轻度低温对大鼠脑缺血的保护作用。Ｗｉｓｔａｒ大鼠在３６．８℃下将四血管阻断１０分钟，低温组３３℃低温再灌流３小时，正常体温组保持在３６．８℃，缺血后第２～６天观察动物行为，第７天处死大鼠进行脑组织病理分析。结果发现，正常体温组神经系统损害积分明显高于低温组，学习记忆能力也明显减退；正常体温组海马ＣＡ１段神经细胞损害率（９１．７％）明显高于低温组（３８．９％）。提示轻度低温对短暂脑缺血后再灌流期脑组织有明显保护作用。We investigated the protective effects of mild hypothermia in cerebral ischemia injury of rats.Three groups of animals were investigated:(1)rats subjected to 10 min of four vessel occlusion(4VO) under normothermia,(2)rats subjected to 10 min of 4VO followed by 330C hypothermic reperfusion for 3h,(3)control rats not subjected to ischemia.The scoring scale of brain injury and water maze test showed that there were more severe behavioral deficits in normothermic rats.The percentage of necrotic neurons in CA1 was analysed 7 days after ischemia.Hypothermic rats exhibited significantly lower neurtic neurons(38.9%) in CA1 compared to the normothmic rats(91.7%,P<0.01).Our data indicated that the mild hypothermia provides protection on behavioral deficits and neuronal injury following transient cerebral ischemia.

关 键 词：轻度低温 脑缺血 再灌注 治疗 大鼠 

分 类 号：R743.305[医药卫生—神经病学与精神病学]