肺癌患者血清血管内皮生长因子与临床病理及动脉血氧分压和血红蛋白关系的研究  

Relationship of serum vascular endothelial growth factor with clinical pathology, PaO_2 and Hb in patients with lung cancer

作　　者：杜岩[1] 周静敏[2] 秦建文[2] 马淑萍[2] 史东升[2] 

机构地区：[1]天津医科大学,300070 [2]天津胸科医院胸内科,300051

出　　处：《实用医学杂志》2008年第6期954-956,共3页The Journal of Practical Medicine

摘　　要：目的:探讨血清血管内皮生长因子(VEGF)在肺癌中的表达及与临床病理和动脉血氧分压(PaO2)及血红蛋白(Hb)的关系。方法:肺癌患者(肺癌组)及健康对照者(对照组)血清VEGF采用双抗体夹心ABC-ELISA法测定。结果:肺癌组血清VEGF测定值高于对照组(P<0.001)。血清VEGF测定值在不同年龄、性别、病理分型、PaO2及Hb含量肺癌患者中差异无显著性(P>0.05),在不同肿瘤直径及有无远处转移肺癌患者间差异有显著性(P<0.01)。肿瘤直径与血清VEGF测定值呈正相关(r=0.633,P<0.001)。结论:VEGF的检测对肺癌的诊断和判断有无远处转移具有一定的临床指导意义。Objective To study the expression of vascular endothelial growth factor(VEGF) and its relation with clinical pathology, PaO2 and Hb in patients with lung cancer. Methods VEGF of 47 patients with lung cancer and 30 healthy controls were measured by sandwich enzyme-linked immunoabsorbentassay (ELISA). Results The serum VEGF level was higher in patients than that in controls (P < 0.001). The VEGF levels were similar in the patients with different age, gender, pathologic type, PaO2, and Hb (P > 0.05), but were not in the patients with different tumor diameter (P < 0.01) and distant metastasis (P < 0.01). Conclusion There is a very important directive significance to detect serum VEGF level for clinical diagnosis and judgement of distant metastasis in patients with lung cancer.

关 键 词：肺肿瘤 血管内皮生长因子类 病理学 

分 类 号：R734.2[医药卫生—肿瘤]