医用器械含氯消毒液消毒性能的研究  

STUDY ON DISINFECTION PROPERTIES OF CHLORINE-CONTAINING INSTRUMENT DISINFECTION SOLUTION

作　　者：李长青[1] 李凤玲[1] 肖潇[1] 蔡丽[1] 阎向东[1] 

机构地区：[1]北京市疾病预防控制中心,北京100013

出　　处：《中国消毒学杂志》2008年第2期137-140,共4页Chinese Journal of Disinfection

摘　　要：目的研究医用器械消毒液对器械的消毒效果及其有关性能。方法采用理化分析方法、载体定量和定性杀菌试验方法、动物毒性试验方法进行了实验室观察。结果该器械消毒液原液有效氯含量为20.9 g/L,经37℃恒温存放90 d后,有效氯含量下降率平均为8.61%。用有效氯含量2000 mg/L该器械消毒液浸泡作用5 min,对载体上枯草杆菌黑色变种芽孢的平均杀灭对数值为4.36;作用20 min,对载体上枯草杆菌黑色变种芽孢可达到完全杀灭。有效氯含量为4000 mg/L该消毒液,作用20 min,对污染于止血钳关节部位上枯草杆菌黑色变种芽孢可达到完全杀灭。用有效氯4000 mg/L该消毒液浸泡72 h,对不锈钢、碳钢、铜、铝等4种金属片基本无腐蚀。该器械消毒液小鼠经口LD50>5000 mg/kg(体重);对小鼠骨髓嗜多染红细胞微核试验结果阴性;该消毒液原液对家兔一次性阴道粘膜刺激试验结果为极轻刺激。结论该器械消毒液性能稳定,毒性低,对金属基本无腐蚀;在常规使用浓度下对载体上细菌芽孢具有较好的杀灭效果。Objective To study the efficacy of medical instrument disinfection solution in disinfection of instruments and its related properties. Methods Physicochemical analytic method, carrier quantitative and qualitative germicidal test metheds and animal toxicity test method were used to carry out laboratory observation. Results The available chlorine content of the stock solution of the instrument disinfection solution was 20.9 g/L and decreased by 8.61% in average after storing at 37℃ constant temperature for 90 days. The average killing logarithm value of Bacillus subtilis vat. niger spores on carrier immersed in the instrument disinfection solution containing available chlorine 2000 mg/L for 5 min was 4.36 and the spores of B. subtilis var. niger on carrier exposed for 20 min could be killed completely. The spores of B. subtilis var. niger on joints of hemostatic forceps exposed to the disinfection solution containing available chlorine 4000 ing/L for 20 min could be killed completely. The four metal coupons including stainless steel, carbon steel, copper and aluminum immersed in the disinfection solution containing available chlorine 4000 mg/L for 72 h were essentially not corroded. The mouse oral LD50 of the instrument disinfection solution was 〉 5000 mg/kg （bw） and its mouse bore marrow polychromatic erythrocyte micronucleus test was negative. The result of stimulating rabbit vagina mucosa once test showed that the stock solution of the disinfection solution was very mild irritating. Conclusions The instrument disinfection solution is stable low toxic, essentially not corrosive to metals. Its solution at conventional concentration has good efficacy in killing bacterial spores on carriers.

关 键 词：器械消毒液 有效氯 稳定性 腐蚀性 细菌芽孢 杀菌效果 

分 类 号：R187.1[医药卫生—流行病学]