An improved method of potential of mean force for protein-protein interactions  

作　　者：SU Yux LI WenFei ZHANG Jian WANG Jun WANG Wei 

机构地区：[1]National Laboratory of Solid State Microstructure and Department of Physics, Nanjing University, Nanjing 210093, China

出　　处：《Chinese Science Bulletin》2008年第8期1145-1151,共7页

基　　金：the National Natural Science Foundation of China (Grant Nos. 90403120, 10474041 and 10504012)

摘　　要：In this work, the traditional method of potential of mean force (PMF) is improved for describing the protein-protein interactions. This method is developed at atomic level and is distance-dependent. Compared with the traditional method, our model can reasonably consider the effects of the environ- mental factors. With this modification, we can obtain more reasonable and accurate pair potentials, which are the pre-requisite for precisely describing the protein-protein interactions and can help us to recognize the interaction rules of residues in protein systems. Our method can also be applied to other fields of protein science, e.g., protein fold recognition, structure prediction and prediction of thermo- stability.In this work, the traditional method of potential of mean force （PMF） is improved for describing the protein-protein interactions. This method is developed at atomic level and is distance-dependent. Compared with the traditional method, our model can reasonably consider the effects of the environmental factors. With this modification, we can obtain more reasonable and accurate pair potentials, which are the pre-requisite for precisely describing the protein-protein interactions and can help us to recognize the interaction rules of residues in protein systems. Our method can also be applied to other fields of protein science, e.g., protein fold recognition, structure prediction and prediction of thermostability.

关 键 词：基础知识 PMF 双蛋白 交互作用 

分 类 号：Q1[生物学—普通生物学]