老年淋巴瘤的内科治疗  

Treatment for elderly lymphOma patients

作　　者：李博[1] 石远凯[2] 

机构地区：[1]中国医学科学院,北京100021 [2]中国协和医科大学肿瘤医院肿瘤研究所内科,北京100021

出　　处：《癌症进展》2008年第2期122-128,共7页Oncology Progress

摘　　要：淋巴瘤在老年患者中并不少见,而且相对于年轻患者,老年淋巴瘤的发病率增高更为明显。虽然在形态学和临床表现上,老年与年轻淋巴瘤患者并无明显区别,但是前者的远期预后更差。这可能与老年患者诊断时更容易合并其他疾病而影响化疗的顺利进行有关。淋巴瘤作为潜在可治愈的肿瘤类型,应给予积极的内科治疗。多项临床研究显示,为了减少化疗的毒副作用而降低药物剂量是不可取的,在积极支持治疗下给予足量化疗可以取得良好的远期疗效,而且,有些药物如美罗华在没有明显增加毒性的情况下进一步改善了化疗疗效,一些新药物被引入临床,也为老年患者提供了更多的选择。Lymphoma is not rare in the aged population. Its incidence is relatively higher when compared with the younger age groups. Although no significant differences exist between older and younger lymphoma patients in terms of morphological and clinical features, the long - term survival is worse in the elderly lymphoma patients, which may be explained by the more freguent and severer degenerative diseases in this population. The efficacy of medical treatment may be compromised by simphy decreasing the doseintensity. Some new agents such Rituximab substantially improve the efficacy without obviously increasing the toxicity and provide more options for elderly lymphoma patients.

关 键 词：淋巴瘤 老年人 化疗 

分 类 号：R733.7[医药卫生—肿瘤]