重症肝炎患者血sIgA和肝脏分泌片的变化  

Change of sIgA in serum and secretory component of liver in severe hepatitis

作　　者：刘冬妍[1] 鲁学恒[2] 刘沛[3] 

机构地区：[1]中国医科大学附属盛京医院实验中心,辽宁沈阳110004 [2]沈阳医学院沈洲医院胃镜中心 [3]中国医科大学附属第一医院内科

出　　处：《中国医科大学学报》2007年第6期689-691,共3页Journal of China Medical University

基　　金：国家自然科学基金资助项目(30670947);辽宁省教育厅高等学校科研基金资助项目(05L466)

摘　　要：目的:研究重症肝炎患者血清IgA、sIgA和肝脏IgA、分泌片(SC)的变化,了解重症肝炎患者血清sIgA升高的原因。方法:血清IgA采用免疫速率比浊法,血清sIgA采用放射免疫分析法,采用免疫组化方法检测肝脏IgA、SC的变化。结果:与对照组相比,血清IgA、sIgA明显升高,肝脏IgA沉积,但肝脏SC无明显变化。结论:重症肝炎时血中sIgA可能是肝脏SC脱落进入胆汁与其内的pIgA结合返流入血形成。Objective：To study the change of IgA,sIgA in serum and IgA,SC of liver in severe hepatitis,and to understand the reason of elevation of serum IgA in severe hepatitis.Methods：The levels of IgA in serum was assayed by immunity rate nephelometry.The levels of sIgA in serum was assayed by radioimmunoassay.IgA and SC of liver were assayed by immunohistochemistry.Results：Compared with the controls,the IgA,sIgA in serum is notably elevated,and IgA was deposited in the liver but SC of liver was not change.Conclusion：In severe hepatitis sIgA in serum was likely that SC of liver was fallen away and was combined with pIgA in bile.Finally sIgA in bile was reflexed into blood.

关 键 词：重症肝炎 免疫球蛋白A 分泌性免疫球蛋白A 分泌片 

分 类 号：R575.4[医药卫生—消化系统]