子宫平滑肌瘤组织中MMP-2、TIMP-2的表达及意义  

Study on the expression and significance of MMP-2,TIMP-2 in the uterine leiomyoma

作　　者：侯书梅[1] 蔺玉红[2] 任翠玲[2] 赵华祥[2] 马红[1] 陈晓[1] 

机构地区：[1]新疆医科大学病理学教研室,新疆乌鲁木齐830011 [2]中国人民解放军第五四六医院,新疆乌鲁木齐841700

出　　处：《河北职工医学院学报》2008年第2期19-21,共3页Journal of Hebei Medical College for Continuing Education

摘　　要：目的研究子宫平滑肌瘤组织中基质金属酶(MMP-2)、基质金属抑制酶(TIMP-2)的表达及意义。方法应用免疫组化S-P法检测50例子宫平滑肌瘤组织中和50例子宫平滑肌组织中MMP-2、TIMP-2的表达。并分析MMP-2、TIMP-2的表达与肌瘤大小个数之间有无密切关系。结果(1)在50例子宫平滑肌瘤组织中MMP-2阳性表达检出率为52.0%(26/50);高于在50例子宫平滑肌正常组织中的阳性表达率28.0(%14/50),(P<0.05)。TIMP-2阳性表达检出率在两组中阳性表达率分别为26.0(%13/50)、20.0(%10/50),表达无差异(P>0.05)(。2)MMP-2阳性表达率与子宫平滑肌瘤个数、大小有一定相关性(P<0.05)。结论提示子宫平滑肌瘤的发生发展与MMP-2、TIMP-2表达有关系。Objective To investigate the expression and significance of MMP-2 TIMP-2 in the uterine leiomyo-ma.Methods 50 cases of uterine leiomyoma tissue,50 cases of normal myometrial tissue were detected for MMP-2,TIMP-2 with immunohistochemisry technique,and relationships between expression of MMP-2,TIMP-2 and some clinical symptoms ware analysed.Results（1）The positive ratio of expression of MMP-2 in 50 cases of uterine leiomyoma tissues was 52.0%（26/50）,which was significantly higher than those in the normal myometrial tissue 28.0%（14/50）,（P〈0.05=,The positive ratio of expression of TIMP-2 in two groups was 26.0%（13/50）、20%（10/50） respectively.There was no difference between two groups（P〉0.05）.（2）Some significant relations were found between the numbers and sizes of the leiomyoma in the uterine and the positive expression levels of MMP-2,P〈0.05.Conclusion（1）The results indicate that there is a close relationship between pathogenesis and development of uterine leiomyomas and the expression levels of MMP-2,TIMP-2 in the uterine leiomyoma tissues.（2）There is a close relationship between clinical signs and the expression levels.（3）There was no signifi-cant difference between the expression levels and the nations.

关 键 词：子宫平滑肌瘤 MMP-2 TIMP-2 

分 类 号：R737.33[医药卫生—肿瘤]