阿尔茨海默病患者Aβ42测定与载脂蛋白E基因关系研究  

Study of the relationship between amyloid β of patients with Alzheimer＇s disease and apolipoprotein E.

作　　者：刘蓉辉[1] 刘卫刚[2] 冯亚青[2] 赵大卫[2] 刘桂芳[2] 哈志远[1] 

机构地区：[1]河北省人民医院医学影像中心,石家庄050000 [2]河北省人民医院老年神经科,石家庄050000

出　　处：《中国综合临床》2008年第4期327-328,共2页Clinical Medicine of China

基　　金：河北省科技厅指导计划项目（062761209）

摘　　要：目的检测阿尔茨海默病（AD）患者血浆中Aβ42妮和载脂蛋白E（ApoE）基因多态性，探讨AD患者体内Aβ42代谢异常情况。方法随机选取AD患者55例、正常人70例，分别检测Aβ42和ApoE基因多态性，并两两进行比较。结果AD组A母42（93．4±7．5）ng／L与对照组（90．5±6．3）ng／L比较，升高差异有统计学意义（P〈0.05）；轻度AD组（94．7±8．5）ng／L与对照组相比，升高差异有统计学意义（P〈0．01）。中重度AD组（87．6±6.9）ng／L与对照组比较，差异无统计学意义（P〉0．05）。结论AD患者Aβ42异常，与疾病的严重程度相关，与ApoE基因不相关。Objective To detect the polymorphism of plasma Aβ42 and apolipoprotcin E （ApoE） of patients with Alzhcimcr＇s disease（AD） , and to explore the abnormal metabolism of Aβ42. Methods 55 AD cases and 70 normal subjects were randomly selected for detection of polymorphism of plasma Aβ42 and ApoE. Results Compared with control group, Aβ42 of AD group was significantly different [ （ 93.4 ± 7.5 ） μg/ml in AD group and （ 90.5 ± 6.3 ） μg/ml in control group （ P 〈 0.05 ）, which was signficantly different in slight AD group （ 94.7 ± 8.5 ） μg/ml as compare with that of control group （ P 〈 0.01 ）, but was not significantly different in moderate AD group （ 87.6 ±6.9 ） μg/ml as compared with that of control group （ P 〉 0.05 ）. Conclusion The abnormal Aβ42 of AD patients is related to the severity of disease but not related to ApoE.

关 键 词：阿尔茨海默病 Β淀粉样蛋白 载脂蛋白E基因 

分 类 号：R749.1[医药卫生—神经病学与精神病学]