缺血性脑卒中危险因素及其控制与临床发病严重程度的关系  

Risk factors and the clinical effect of therapies for the initial ischemic stroke of various severity

作　　者：王艳[1] 王伊龙[2] 吴敌[2] 王拥军[2] 

机构地区：[1]华北煤炭医学院附属医院脑电图室,河北省唐山市063000 [2]北京天坛医院神经内科

出　　处：《中国综合临床》2008年第4期346-349,共4页Clinical Medicine of China

摘　　要：目的探讨脑卒中危险因素及其治疗情况对首次发生缺血性卒中患者临床病情严重程度的影响。方法2006年2月至2007年2月连续收集急性缺血性脑卒中患者272例，均采用统一的访谈式向卷调查卒中患者的危险因素及其治疗情况，并采集患者入院后神经功能缺损（NIHSS）评分。结果单变量分析发现两组间性别、年龄、短暂性脑缺血发作（TIA）治疗、心房颤动、糖尿病、吸烟史、饮酒史、久坐生活方式、小动脉粥样硬化性（SVO）、心源性卒中（CE）水平间差异有统计学意义（P〈0．05）。多元非条件Logistic回归分析发现吸烟史、TIA治疗、CE是严重型卒中的独立危险因素。结论吸烟史、TIA治疗史、CE是独立危险因素，应进行大样本队列研究加以证实。Objective To investigate risk factors of stroke and previous treatments to the effect of clinical severity in the first ischemic stroke. Methods 272 first ischemic stroke were admitted from Feb. 2006 to Feb. 2007 The standard of cerebral infarction diagnosis accorded with the one which was constituted . All the subjects were surveyed with questionnaires and risk factors and previous treatments were collected. Stroke severity was evaluated by national Institute of Health Stroke Scale （ NIHSS ）. Results Univariate analysis showed there were differences between fatal stroke and non-fatal stroke in sex,age,the treatment of TIA,artrial fibrillation,diabetes,cigarette smoke, alcohol abuse,long-sitting lifestyle groups, SVO, and CE （ P 〈 0. 05 ）. Multivariate logistic regression analysis found that cigarette smoke,treatment of TIA,and CE were independent risk factors of clinical severity in the first isehemic stroke. Conclusion Cigarette smoking, treatment of TIA, CE are independent risk factors of clinical severity in the initial ischemic stroke. Large sample cohort study needs to be conducted to confirm the hypothesis.

关 键 词：缺血性脑卒中 危险因素 神经功能缺损评分 TOAST分型 

分 类 号：R743.3[医药卫生—神经病学与精神病学]