2型糖尿病中医辨证分型与胰岛素抵抗及生长抑素的关系  

Relationship among Differentiation for Syndrome Classification,Insuiin Resistance and Somatostatin in Type 2 Diabetes

作　　者：周金虎[1] 姚定国[1] 李欣[1] 

机构地区：[1]浙江中医药大学第一临床医学院,杭州310053

出　　处：《浙江中西医结合杂志》2008年第4期203-205,共3页Zhejiang Journal of Integrated Traditional Chinese and Western Medicine

摘　　要：目的：对2型糖尿病（T2DM）患者的血清生长抑素（SS）与胰岛素抵抗（IR）及中医辨证分型的相互关系进行探讨。方法：我院内分泌科住院和门诊T2DM患者100例，男51例，女49例，年龄34—75岁，平均60．5岁。按照2002年国家药品监督管理局制定的《新药（中药）治疗消渴病（DM）临床研究指导原则》，结合临床观察分为阴虚热盛、湿热困脾、气阴两虚、阴阳两虚4型。观察对象在检测前1周内未服用糖皮质激素、β受体激动剂等影响神经、内分泌功能的药物。在前1天停用一切药物，于次日上午8时前空腹抽取肘静脉血10ml，测定空腹血糖（FBG）、空腹胰岛素（FINS）、SS。结果：T2DM各证型均存IR，以阴阳两虚组及湿热困脾组较高，阴阳两虚组显著高于其他四组，湿热困脾组则显著高于阴虚热盛和气阴两虚组。T2DM各证型SS均低于正常对照组，但四组之间SS差异无显著性意义。通过Pearson相关性分析，IR与FBG、FINS、胰岛素敏感性指数（IAI）、SS、病程等变量有相关性，与FBG、FINS呈正相关；IR与IAI、SS、病程呈负相关，其中与SS的相关系数r=-0．1988。结论：IR与FBG、FINS、IAI、SS、病程等变量有相关性，SS是重要的IR决定因素。Objective： To investigate the relationship among differentiation for syndrome classification, insulin resistance and somatostatin in type 2 diabetes. Methods： 100 cases of type 2 diabetes with 51 cases male and 49 cases female were chosen and the average age Was 60.56. According to the guiding principles Of new medicine （TCM）in the treatment of diabetes disease（DM） developed by the national drug administration in 2002 and clinical observation, syndromes of 100 patients were divided into four types ： Yinxu-resheng, Shire-kunpi, Qiyin-liangxu and Yinyang-liangxu. Patients stopped to take drugs effecting nerve and endocrine function such as glucocorticoid and beta-agonist one week before examination and stopped all drugs one day before examination. 10 ml elbow venous blood was taken before 8 o＇ clock. FBG was observed by glucose oxidese method. FINS and SS were observed by RIA analysis method. Results：Pearson correlation analysis showed that IR was correlated with FBG FINS, IAI, SS, duration and other variables. Among them, IR was positively correlated with FBG and FINS, and negatively correlated with IAI, SS and duration. The correlation coefficient between IR and SS was r = - 0. 1988, which showed SS was an important IR deciding factor. Conclusion： IR is correlated with FBG, FINS, IAI ,SS, duration and other variables. Among them, SS is an important IR deciding factor.

关 键 词：2型糖尿病 血清生长抑素 胰岛素抵抗 中医理论 

分 类 号：R259[医药卫生—中西医结合]