癌相关成纤维细胞与肿瘤细胞相互作用对肿瘤发生发展的影响  

Interaction of cancer-associated fibroblasts and tumor cells in carcinogenesis

作　　者：武剑[1] 邓红[1] 

机构地区：[1]浙江大学医学院病理学教研室,浙江杭州310058

出　　处：《浙江大学学报（医学版）》2008年第2期212-217,共6页Journal of Zhejiang University(Medical Sciences)

摘　　要：间质细胞与细胞外基质成分构成的肿瘤微环境对肿瘤细胞的生长、浸润和转移具有重要作用。特征性间质改变通常伴随甚至先于上皮细胞的恶变。这一过程中的关键成分——活化的成纤维细胞,又称为肌成纤维细胞或者癌相关成纤维细胞,是肿瘤间质中数量最丰富的细胞类型,它们通过细胞与细胞间相互接触,在各种可溶性因子的媒介作用下,促进上皮细胞恶性转化。文中主要介绍癌相关成纤维细胞及其在肿瘤发生发展中的作用。Tumor microenvironment is composed of mesenchymal cells and extracellular matrix components ,which plays an important role in the growth ,invasion and metastasis of tumor cells. Characteristic changes of stroma are usually accompanied with the malignant transformation of epithelial cells even ahead. The key component in the process- activated fibroblasts,also known as myofibroblasts, or cancer-associated fibroblasts （CAF）,is the most abundant cells in tumor stroma. They promote the malignant transformation of epithelial cells through cell-cell communication via various soluble factors. This article reviews cancer-associated fibroblasts and their role in tumor development.

关 键 词：成纤维细胞 肿瘤 癌相关成纤维细胞 肌成纤维细胞 细胞间相互作用 生长因子 综述 

分 类 号：R730.2[医药卫生—肿瘤]