Rho／ROCK与神经系统疾病  

Rho/ROCK and Neurological Diseases

作　　者：唐华[1] 赵合庆[1] 

机构地区：[1]苏州大学附属第二医院神经内科,215004

出　　处：《国际脑血管病杂志》2008年第3期233-236,共4页International Journal of Cerebrovascular Diseases

摘　　要：作为一种分子开关，Rho可在无活性的GDP结合形式和有活性的GTP结合形式之间转换，传递信号给下游底物Rho激酶（ROCK），介导特殊的生物学效应，参与多种神经系统疾病，如缺血性卒中、脑血管痉挛、脊髓损伤后轴突再生的病理学过程。应用ROCK抑制剂治疗神经系统疾病已取得满意效果。Rho／ROCK有望成为一个新的治疗靶点。As a molecular switch, Rho can be transformed between the inactive GDP-bound form and the active GTP-bound form, transfering signals to downstream effector Rho kinase （ROCK）, mediating specific biological effects, and participating in various neurological diseases, such as the pathological processes of ischemic stroke, cerebral vasospasm, and axonal regeneration after spinal cord injury. The application of ROCK inhibitor in the treatment of neurological diseases has achieved satisfactory effect. Rho/ROCK is expected to become a novel therapeutic target.

关 键 词：RHO激酶 脑血管病 轴突再生 

分 类 号：R741[医药卫生—神经病学与精神病学]