肿瘤标志物Bcl-2和c-erbB-2在乳腺癌中的表达及其临床意义  

Expression of Bcl-2 and c-erbB-2 in breast cancer and its clinical significance

作　　者：侯金超[1] 薄爱华[1] 王发亮[1] 吴力娟[1] 吴迎爽[1] 周宁[1] 

机构地区：[1]河北北方学院,河北张家口075000

出　　处：《实用肿瘤杂志》2008年第2期139-141,共3页Journal of Practical Oncology

基　　金：河北省张家口市科技厅资助项目(No:061158)

摘　　要：目的探讨肿瘤标志物Bcl-2和c-erbB-2在乳腺癌中的表达和两者的相关性。方法应用免疫组化方法对70例乳腺恶性肿瘤标本和24例纤维腺瘤标本进行Bcl-2和c-erbB-2癌基因蛋白检测。结果Bcl-2和c-erbB-2在乳腺癌中的阳性率分别为68.1%和67.1%;在纤维腺瘤中的阳性率分别为87.5%和0%。Bcl-2和c-erbB-2的阳性表达与有无淋巴结转移呈显著相关。乳腺癌中Bcl-2和c-erbB-2的阳性表达呈负相关(r=-0.28)。结论乳腺癌中Bcl-2的高表达提示患者的预后较好,c-erbB-2的高表达提示患者预后较差。Objective To investigate the expression of Bcl-2 and c-erbB-2 in breast cancer and its clinical significance. Method Expressions of Bcl-2 and c-erbB-2 protein were examined immumohistochemically in 70 cases of malignant breast neoplasm and 24 of breast fibroadenoma. Results The positive expression rates of Bcl-2 and c-erbB-2 in breast cancer were 68. 6% and 67. 1%, those in the breast fibroadenoma were 87. 5% and 0%. The expressions of Bcl-2 and c-erbB-2 were related to lymph node metastasis. The expression of Ecl-2 was negatively correlated with that of c-erbB-2 （r=-0.28）. Conclusion Overexpression of Bcl-2 is associated with better prognosis of patients with breast cancer; and high expression of c-erbB-2 is associated with worse prognosis.

关 键 词：乳腺肿瘤/病理学 基因 BCL-2 免疫组织化学 基因 ERBB-2 基因表达 

分 类 号：R737.9[医药卫生—肿瘤]