强迫症患者GO／NOGO任务的事件相关电位研究  

Event-related Potentials of Obsessive-Compulsive Disorder Patients in a GO/NOGO Task

作　　者：王晓燕[1] 陈斌[2] 朱熊兆[3] 姚树桥[3] 

机构地区：[1]海军总医院卫生防疫队,北京101113 [2]湖南省人民医院心理科,长沙410005 [3]中南大学湘雅二医院医学心理研究中心,长沙410011

出　　处：《中国心理卫生杂志》2008年第4期276-280,共5页Chinese Mental Health Journal

基　　金：中国科学院知识创新工程重要方向资助项目(KSCXZ2SW2221);湖南省卫生厅基金资助项目(B20042050)

摘　　要：目的:探讨强迫症患者执行GO/NOGO任务时所诱发的事件相关电位(ERPs)特点,初步探讨GO/NOGO任务所诱发的ERP成分与脑反应抑制过程的关系。方法:记录22名强迫症患者和21名正常对照在执行线索引导的视觉GO/NOGO任务时诱发的ERPs。该任务序列包括400个刺激,需要被试作出反应的GO刺激及需要被试抑制反应的NOGO刺激各占10(。结果:强迫症患者在GO任务中的平均反应时长于正常对照组(351.0±56.8/307.1±53.5ms,t=2.605,P=0.013),但反应错误数与正常对照组差异不显著(2.5±2.3/1.5±1.7,t=1.626,P=0.112)。强迫症患者的GO-P3波幅与对照组差异无统计学意义(P>0.05),但NOGO-P3波幅在FZ、FCZ、FC3、FC4点较对照组降低(16.0±7.6/20.1±5.7,19.2±8.6/24.7±6.3,14.6±6.3/18.4±5.6,15.7±6.8/20.8±5.7,t=-2.01^-2.65,均P(0.05),强迫症患者的GO/NOGO-P3潜伏期与正常对照组差异无统计学意义(P>0.05)。强迫症患者颅脑电位分布范围小于正常对照,其中以NOGO任务额区脑电活动减弱为明显。结论:强迫症患者GO/NOGO任务所诱发的事件相关电位表现异常。NOGO-P3可能是反应额叶反应抑制过程的重要成分。Objective：To investigate the ERPs of patients with OCD （ obsessive-compulsive disorder）when performing GO/NOGO task and discuss the relationship between components of ERPs and the process of response-inhibition. Methods：ERPs were recorded in 22 OCD patients and 21 normal controls while they performed a visual cued GO/ NOGO task. This task consists of 400 trials and 40 of it were target stimulus. Results：The OCD group had longer reaction time than control group in GO task （351.0 ± 56.8/307. 1 ± 53. 5 ms, t = 2. 61 , P = 0. 013） , but the two groups had no significant difference in number of errors （ 2. 5 ± 2. 3/1.5±1.7, t = 1.63, P = 0. 112）. The ERPs demonstrated similar waveform （ P3 ） between OCD patients and normal group , the amplitudes of GO-P3 had no significant difference either. But amplitudes of NOGO-P3 in OCD patients were significantly decreased compared with that in normal controls at FZ, FCZ, FC3 and FC4 （ 16. 0 ± 7. 6/20. 1± 5.7,19.2± 8.6/24. 7 ± 6. 3,14. 6±6. 3/18. 4 ± 5.6,15.7 ± 6. 8/20. 8± 5.7 ,t = -2. 01 - -2. 65, P 〈 0. 05） The latent period had no significant difference between the two groups in both GO and NOGO task. The above data means both group had same landscape in scalp topography, but NOGO-P3 of the patients had smaller amplitude over the central frontal regions. Conclusion：The findings provided electrophysiological eqidence that cognitive dysfunction of frontal cortex existed in OCD patients, and NOGO-P3 perhaps the important component reflect the response-inhibition process.

关 键 词：事件相关电位 视觉 强迫症 GO/NOGO任务 病例对照研究 

分 类 号：R749.79[医药卫生—神经病学与精神病学]