Pre-S_2抗原与乙肝病毒血清标志物关系新探  

New Research on Relationship between Hepatitis B virus Pre-S_2 Antigen and HBV serum Markers

作　　者：王剑[1] 吴阿阳 林永富[1] 吴德荣[1] 蔡韶滨[1] 盘晓娟[1] 刘平娥[3] 唐冬英[3] 彭丽花[3] 陈友元[3] 

机构地区：[1]漳州卫生职业学院,福建363000 [2]漳州市人民医院 [3]湖南省永州职业技术学院

出　　处：《中国预防医学杂志》2008年第1期37-39,共3页Chinese Preventive Medicine

基　　金：漳州市科技进步奖立项项目

摘　　要：目的探讨Pre-S2抗原(前S2抗原)在乙型肝炎病毒的各类隐性、显性感染中的地位及科研、临床应用价值。方法以乙肝病毒隐性感染者(为主)及适量显性感染者作为研究对象,采用ELISA(酶联免疫吸附试验)法,同时检测感染者的Pre-S2抗原和乙肝血清标志物,然后进行各类、群感染者之间的比较、分析。结果在乙肝病毒隐性感染者人群中,乙肝e抗原阳性人员、e抗体阳性人员的Pre-S2抗原阳性率分别为93.10%、60.00%;"乙肝大三阳"人员、"小三阳"人员的Pre-S2抗原阳性率分别为92.31%、62.50%。在乙肝病毒显性感染者——急、慢性乙肝患者两类对比人群中,Pre-S2抗原的阳性率分别为90.91%、61.54%。结论Pre-S2抗原在判断乙肝病毒突变、感染者尤其是隐性感染者血清的传染性强度方面,有较高使用价值和补缺作用;在判断隐性感染者的发展转化和显性感染者的临床转归方面,亦有较大参考意义。Objective To explore clinical significance of Pre-S2 antigen in inapparent and apparent hepatitis B virus infections. Methods Pre-S2 antigen and HBV serum markers of inapparent and apparent hepatitis B virus infection cases were detected by enzyme linked irranunosorhent assay. Results In cases with inapparent hepatitis B virus infection, co-positive rate of Pre-S2 antigen and HBeAg was 93.10%, and of Pre-S2 antigen and HBeAb was 60.00% .The positive rates of Pre-S2 antigen in people with positive HBsAg, HBcAB and people with positive HBsAg, HBeAb, HBcAg were 92.31% and 62.50%, respectively.While the positive rates of Pre-S2 antigen in acute and chronic hepatitis B patients were 90.91% and 61.54% respectively. Conclusion Pre-S2 antigen has great significance in detection of mutation and serum infection ability of hepatitis B virus infection cases （especially in inapparent infection cases）. Meanwhile, it also has obvious significance in judging changing and clinical outcomes of inapparent hepatitis B patients.

关 键 词：乙肝病毒 隐性感染 前S2抗原 显性感染 血清 

分 类 号：R512.62[医药卫生—内科学] R512.620.3[医药卫生—临床医学]